NDLI: Metabolic effects of pioglitazone in chemically-induced mammary carcinogenesis in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bojková, Bianka Garajová, Miroslava Péc, Martin Kubatka, Peter Kajo, Karol Mokán, Marián Kassayová, Monika Orendás, Peter Kisková, Terézia Ahlersová, Eva Ahlers, Ivan
Description	Author Affiliation: Bojková B ( Department of Animal Physiology, Institute of Biology and Ecology, Faculty of Science, P.J.Safárik University, Moyzesova 11, 041 67 Kosice, Slovak Republic. bianka.bojkova@upjs.sk)
Abstract	In this paper, the effect of peroral antidiabetic pioglitazone, a thiazolidinedione derivate, on selected parameters of carbohydrate and lipid metabolism in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats was evaluated. Pioglitazone was administered in the diet at two concentrations (10 ppm and 100 ppm), the chemoprevention was initiated 12 days before carcinogenesis induction and lasted until the termination of the experiment. The experiment was terminated 17 weeks after carcinogenesis induction, selected organs and tissues were removed and weighed and basic metabolic and hormonal parameters were determined. Pioglitazone increased glycemia (without exceeding normal values) and glycogen concentration in both liver and heart muscle without altering insulinemia and increased triacylglycerol concentration in liver, these changes were more prominent in group with higher dose. Pioglitazone also reduced corticosterone serum concentration and attenuated lipid peroxidation. Pioglitazone and other glitazones may be useful in alleviation of unfavourable metabolic changes in cancer patients.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Mammary Neoplasms, Experimental Drug Therapy Metabolism Thiazolidinediones Pharmacology Animals Corticosterone Blood Female Glycogen Heart Drug Effects Hyperglycemia Chemically Induced Hyperinsulinism Lipid Peroxidation Liver Methylnitrosourea Muscles Myocardium Rats Rats, Sprague-dawley Triglycerides Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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