NDLI: Stem cell associated genes working with one miRNA cluster have different clinic pathologic values in gastric cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Qiong Yang, Zhiping Hu, Sijun Su, Tao An, Yanxin Zhang, Zhiyong Nie, Yongzhan Wang, Xin Shi, Yongquan Fan, Daiming
Description	Country affiliation: China Author Affiliation: Wu Q ( State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi 710032, China.)
Abstract	Cancer stem cells are nowadays considered to be the origin of cancer. Also, stem cell associated genes are emerging as predictors of cancer malignancy. We investigated the association of several stemness genes (c-Myc, PTEN, p57 and p21) with clinic pathological parameters and survival in stomach cancer by performing immunohistochemistry on paraffin sections of gastric cancer patients who underwent surgical staging with following-up statistics. We discovered that expression of c-Myc was significantly related to distant metastasis, the combined expression of PTEN and p21 correlated positively to overall survival, while p57 was less useful in overall survival prediction in gastric cancer. Additionally, there is a positive correlation between expressions of p57 and p21. In conclusion, our present study indicated that expression of stemness genes (c-Myc, PTEN, p57 and p21) performed different predictive potential in the evaluation of clinical malignancy levels in gastric cancer.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Micrornas Genetics Neoplastic Stem Cells Physiology Stomach Neoplasms Pathology Adult Aged Aged, 80 And Over Cyclin-dependent Kinase Inhibitor P21 Cyclin-dependent Kinase Inhibitor P57 Female Follow-up Studies Humans Immunohistochemistry Methods Male Middle Aged Neoplasm Metastasis Metabolism Pten Phosphohydrolase Prognosis Proto-oncogene Proteins C-myc Survival Rate Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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