NDLI: Invasion of the hypoglossal nerve by adenoid cystic carcinoma of the tongue: case report and review of the literature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Shu-Wei Guo, Zhu-Ming Zhang, Quan Yang, An-Kui Li, Qiu-Li Zhuang, Shi-Min Wang, Li-Ping Song, Ming
Description	Author Affiliation: Chen SW ( State Key Laboratory of Oncology in South China and Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Dong Road, Guangzhou 510060, People's Republic of China.)
Abstract	Adenoid cystic carcinoma (ACC) is a rare but highly aggressive malignancy mainly originating from the salivary glands. ACC is well known for its propensity toward neural invasion (NI). NI is the process of neoplastic invasion in and along nerves. It is a distinct and well-documented phenomenon in ACC; however, it is an underestimated route of metastatic spread. Multiple distant metastases can be established through NI route, and NI is believed to portend a poor prognosis. Despite increasing recognition of NI in many malignancies, the molecular mechanism behind NI is not well established. We present a unique case of hypoglossal nerve invasion by ACC arising from the minor salivary glands in the tongue of a 34-year-old man. We also review and discuss current theories on the pathogenesis and mechanism of NI.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Adenoid Cystic Pathology Hypoglossal Nerve Neoplasm Invasiveness Tongue Innervation Adult Secondary Humans Male Salivary Gland Neoplasms Salivary Glands, Minor Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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