NDLI: Tumornecrosis-factor- 308 GA polymorphism in atherosclerotic patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Szabó, Gábor Viktor Acsády, György
Description	Country affiliation: Hungary Author Affiliation: Szabó GV ( Department of Cardiovascular Surgery of Semmelweis University, Városmajor str. 68, 1122 Budapest, Hungary. szabogvdr@gmail.com)
Abstract	The development of the atherosclerosis is a multifactorial process, where the clinical pattern is determined by environmental and genetic factors. Except for the classical risk factors of atherosclerosis (hypertension, lipid-metabolic disorders, diabetes, smoking) the clinical signs can be influenced by the genetic variants (polymorphisms) of the enzymes, which are responsible for the endothelial cell function and for the thrombotic factors. In our examination our aim was to define the TNF- 308GA polymorphisms in atherosclerotic diabetic, atherosclerotic non-diabetic and healthy patients. We found correlation of the frequency of myocardial infarction and stroke in atherosclerotic diabetic and atherosclerotic non-diabetic patients. We proved that among patients with mutant TNF- AA genotype the occurrence of cardiovascular events is significantly higher: Mutant AA homozygous genotype: control group 1, 6%, MI group 10,7%, p < 0,005, OR: 8,17 versus Normal GG allele: control group 76,7%, MI group 61,3%. The TNF- AA genotype can have a clinical importance as a prognostic and therapeutic marker, although further studies are needed to confirm this hypothesis.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Atherosclerosis Genetics Tumor Necrosis Factor-alpha Adult Aged Aged, 80 And Over Alleles Case-control Studies Diabetes Mellitus, Type 2 Genetic Predisposition To Disease Genotype Humans Middle Aged Mutation Myocardial Infarction Polymorphism, Genetic Prognosis Risk Factors Stroke Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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