NDLI: Roles of hormones and signaling molecules in describing the relationship between obesity and colon cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sikalidis, Angelos K. Varamini, Behzad
Description	Country affiliation: United States Author Affiliation: Sikalidis AK ( Division of Nutritional Sciences, Cornell University, 214 Savage Hall, Ithaca, NY 14853, USA. as545@cornell.edu)
Abstract	Colon cancer represents a highly prevalent disease in the Western world. While dietary and lifestyle recommendations remain important factors in disease prevention and treatment, epidemiological data have made it clear that obesity and excess body weight remain significant risk factors for the disease. A number of potential direct and indirect relationships exist between obesity and increased risk of colon cancer. Several mechanisms which appear promising and warrant further investigation are discussed here, specifically the modifying role of insulin and insulin-like growth factors, leptin, adipose-tissue induced changes in estrogens and androgens, and inflammatory molecules. A brief review of these hormones and signaling molecules and their action in colon cancer development is described. A thorough integration and understanding of the mechanisms of action these systems exert on colonic epithelia will be important in designing studies and experiments aimed at elucidating disease etiology for prevention and treatment.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Colonic Neoplasms Etiology Metabolism Hormones Obesity Complications Animals Humans Risk Factors Signal Transduction Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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