NDLI: Lymphatic differentiation in classic Kaposi's sarcoma: patterns of D2-40 immunoexpression in the course of tumor progression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kandemir, Nilufer Onak Barut, Figen Gun, Banu Dogan Keser, Sevinc Hallac Karadayi, Nimet Gun, Mustafa Ozdamar, Sukru Oguz
Description	Country affiliation: Turkey Author Affiliation: Kandemir NO ( Department of Pathology, School of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak 67600, Turkey. niluferkandemir@yahoo.com)
Abstract	The recent development of lymphatic endothelium-specific immuno-indicators has given rise to research on the histogenesis of Kaposi sarcoma (KS), specifically focusing on its lymphatic root and differentiation. D2-40 is a new lymphatic marker that recognizes podoplanin and is easily applied to formalin-fixed paraffin-embedded human tissues. This study examined D2-40 immunoexpression in 178 classical KS lesions using immunohistochemical methods. D2-40 immunoexpression was also examined in 63 non-KS soft tissue lesions to test the reliability of D2-40 monoclonal antibody in the pathological diagnosis of KS. D2-40 immunoreactivity was detected at all of the KS lesions and in lymphangioma and nonneoplastic lymphatic endothelium. There was no significant relationship between the extent of D2-40 staining and histopathological stage; however, there was a positive correlation between the staining intensity and histopathological stage in KS cases. D2-40 immunoreactivity was detected at all histopathological stages of KS and may be added to the routine immunohistochemical panel used for the differential diagnosis of KS. Widespread D2-40 protein expression is evidence of a lymphatic origin or the differentiation of neoplastic cells in KS, and D2-40 expression increases with tumor progression.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antibodies, Monoclonal, Murine-derived Biosynthesis Lymphatic Vessels Pathology Sarcoma, Kaposi Immunology Tumor Markers, Biological Analysis Cell Differentiation Disease Progression Endothelium, Lymphatic Humans Immunohistochemistry Methods Lymphangioma Membrane Glycoproteins Neoplasm Staging Paraffin Embedding Soft Tissue Neoplasms Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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