NDLI: Let-7 g is involved in doxorubicin induced myocardial injury.

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Let-7 g is involved in doxorubicin induced myocardial injury.

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Let-7 g is involved in doxorubicin induced myocardial injury.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fu, Jun Peng, Cike Wang, Wanyi Jin, Haifeng Tang, Qiuqiong Wei, Xuetao
Description	Author Affiliation: Fu J ( Department of Toxicology, Health Science Center, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, PR China.)
Abstract	OBJECTIVES: To investigate whether let-7 g (miRNA) was involved in doxorubicin-induced cardiotoxicity. METHODS: Rats were treated with doxorubicin at increasing doses (0mg/kg, 6 mg/kg, 12 mg/kg, 18 mg/kg). Heart rate, pulse pressure and plasma cardiac troponin T concentrations were measured. Primary cultured myocardial cells were incubated with DOX at increasing concentrations (0 µmol/l, 0.004 µmol/l, 0.02 µmol/l, 0.1 µmol/l, 0.5 µmol/l) for 24h. Cellular viability and the beat frequency were measured. For both rats and cultured cells, miRNA content was measured by real-time reverse-transcription PCR. RESULTS: All DOX-treated rats had a decrease in heart rate, an increase in pulse pressure compared with control group after injections (p<0.05). Concentration of cTnT was increased significantly in 18 mg/kg group. Content of let-7 g decreased significantly (p<0.05) in 18 mg/kg group in vivo and all the doxorubicin treated group in vitro. CONCLUSIONS: The down regulation of let-7 g in the myocardial-injury model suggests that let-7 g may play an important role in the development of cardiac disease.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	33
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Antibiotics, Antineoplastic Doxorubicin Heart Diseases Genetics Micrornas Metabolism Myocytes, Cardiac Animals Blood Pressure Cell Survival Cells, Cultured Disease Models, Animal Down-regulation Chemically Induced Pathology Physiopathology Heart Rate Male Rats Rats, Wistar Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Time Factors Troponin T Blood Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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