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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhu, Huifang Fan, Yanfeng Shen, Jing Qi, Hongyan Shao, Jimin |
| Description | Country affiliation: China Author Affiliation: Zhu H ( Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.) |
| Abstract | DNA polymerase κ (Pol κ), a member of Y-family DNA polymerases, can synthesize DNA with moderate fidelity on undamaged DNAs and replicate accurately in vitro thymine glycol, 8-oxo-G and aromatic adducts such as benzo[a]pyrene diol epoxide (BPDE). However, few studies have been done on the transcriptional regulation of Pol κ. In this study, we predicted and cloned the promoter region of the human POLK gene. Through the analysis of deletion constructs of the POLK promoter, we demonstrated that the region -336/-141 contained repressing elements and the region -141/+226 contained positive regulatory elements for transcription of human Pol κ. Furthermore, quantitative RT-PCR showed that human POLK mRNA expression was dysregulated in FL cells treated by BPDE. The transcriptional activities of the POLK promoter regions -336/+437 and +20/+437 were significantly reduced by BPDE treatment, indicating that transcription factors in this two regions, such as HSF1, may regulate the transcription of human POLK gene in response to BPDE. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 2 |
| Volume Number | 33 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Toxicity Carcinogens, Environmental Dna-directed Dna Polymerase Genetics Epithelial Cells Enzymology Promoter Regions, Genetic Drug Effects Base Sequence Binding Sites Cells, Cultured Cloning, Molecular Computational Biology Metabolism Genes, Reporter Humans Luciferases, Firefly Molecular Sequence Data Rna, Messenger Real-time Polymerase Chain Reaction Transcription, Genetic Transfection Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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