NDLI: Evaluation of the effect of Uncaria tomentosa extracts on the size and shape of human erythrocytes (in vitro).

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Evaluation of the effect of Uncaria tomentosa extracts on the size and shape of human erythrocytes (in vitro).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bors, Milena Sicinska, Paulina Michalowicz, Jaromir Wieteska, Paulina Gulewicz, Krzysztof Bukowska, Bozena
Description	Country affiliation: Poland Author Affiliation: Bors M ( Department of Environmental Pollution Biophysics, Pomorska 141/143 St., 90-237 Lódz, Poland.)
Abstract	In this study, we continued our investigations concerning the interaction of Uncaria tomentosa extracts with the human erythrocytes. The analysis of the size and shape of the erythrocytes by means of flow cytometry and phase contrast microscopy was performed. We executed our experiments using ethanolic and aqueous extracts from the leaves and bark of U. tomentosa. Disturbances were observed in the size and shape of the erythrocytes incubated with ethanolic and aqueous extracts at the concentrations of 100 µg/mL and 250 µg/mL, respectively. The observed changes were probably related to the entry of polyphenolic compounds contained in U. tomentosa extracts into erythrocyte membrane. Externalization of phosphatidylserine on the erythrocytic surfaces was also noticed during incubation with extracts at concentration of 250 µg/mL. We concluded that all of the extracts examined induced changes in the erythrocyte membrane properties, whereas ethanolic extracts from bark induced the most significant changes. The possible binding of polyphenols to the erythrocyte surface may have accounted for the protective properties of extracts against haemolysis of RBCs, which was observed in our previous study (Bors et al., 2011), but considerable incorporation of polyphenols into cell membranes can result in disturbance of phosphatidylserine transport and changes in erythrocyte shape. Nevertheless the results of the investigations showed that considerable morphological changes appear only as a result of erythrocyte exposure to high concentrations (50 ppm and 100 ppm) of the extracts studied, thus they should not lead to clinical erythrocytic damage if recommended doses of U. tomentosa preparations are administrated.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	33
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Cat's Claw Cell Shape Drug Effects Cell Size Erythrocytes Plant Extracts Pharmacology Polyphenols Dose-response Relationship, Drug Erythrocyte Indices Erythrocyte Membrane Metabolism Ethanol Chemistry Flow Cytometry Humans Microscopy, Phase-contrast Phosphatidylserines Plant Bark Plant Leaves Plants, Medicinal Solvents Water Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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