NDLI: Formation of a 3,4-diol-1,2-epoxide metabolite of benz[a]anthracene with cytotoxicity and genotoxicity in a human in vitro hepatocyte culture system.

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Formation of a 3,4-diol-1,2-epoxide metabolite of benz[a]anthracene with cytotoxicity and genotoxicity in a human in vitro hepatocyte culture system.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Song, Mi-Kyung Kim, Youn-Jung Song, Mee Choi, Han-Seam Park, Yong-Keun Ryu, Jae-Chun
Description	Author Affiliation: Song MK ( Cellular and Molecular Toxicology Laboratory, Korea Institute of Science & Technology, PO Box 131, Cheongryang, Seoul, 130-650, Republic of Korea.)
Abstract	Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that require metabolic activation to exert their carcinogenic effects. This study investigated the 3,4-diol-1,2-epoxide formation of benz[a]anthracene (BA) and its toxic effects in a human in vitro hepatocyte culture system. Both mRNA and protein expression of metabolic enzymes which can activate PAHs to carcinogenic forms increased after BA exposure in HepG2 cells and our quantitative analysis showed that the formation of BA-3,4-diol-1,2-epoxide in medium extracts increased in a time-dependent manner. We also performed several comparative studies which show that much lower concentrations of BA-3,4-diol-1,2-epoxide had stronger cytotoxicity and genotoxicity than higher doses of BA. These results suggest that BA is activated as the major carcinogenic metabolite 3,4-diol-1,2-epoxide, in human in vitro culture systems by metabolic enzymes and that this metabolite has stronger cytotoxic and genotoxic effects than its parent compound.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	33
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Benz(a)anthracenes Toxicity Carcinogens, Environmental Hepatocytes Drug Effects Mutagens Alcohol Oxidoreductases Biosynthesis Genetics Apoptosis Metabolism Biotransformation Cell Cycle Cells, Cultured Comet Assay Cytochrome P-450 Enzyme System Dna Damage Dose-response Relationship, Drug Enzyme Induction Hep G2 Cells Pathology Humans Rna, Messenger Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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