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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Belij, Sandra Popov, Aleksandra Zolotarevski, Lidija Mirkov, Ivana Djokic, Jelena Kataranovski, Dragan Kataranovski, Milena |
| Description | Author Affiliation: Belij S ( Department of Ecology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia.) |
| Abstract | Topical application of dinitrochlorobenzene (DNCB) is employed in the immunotherapy of skin diseases. Activation of T-cell mediated immune responses (Th1/type1) is the supposed mechanism of the clinical effect of DNCB, but there are no data concerning innate/inflammatory mechanisms. In this study, the effect of repeated topical DNCB application on peripheral blood polymorphonuclear (PMN) leukocytes has been examined in two rat strains which differ in the propensity to mount Th1/type1 or Th2/type2 responses. The dynamics of changes in PMN numbers and effector activities (respiratory burst, nitric oxide production and myeloperoxidase content), as well as in adhesion and TNF- production following the rat skin sensitization with low (0.4%) and high (4%) DNCB doses were measured. Both priming and activation of PMNs were observed following skin sensitization with DNCB, with dose-dependent as well as time-dependent differences in some PMN activities. Obtained data might be relevant for understanding the immune mechanisms of topical DNCB therapy. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 2 |
| Volume Number | 33 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Dermatitis, Contact Etiology Dinitrochlorobenzene Administration & Dosage Immunologic Factors Neutrophil Activation Drug Effects Neutrophils Skin Administration, Cutaneous Animals Cell Adhesion Immunology Metabolism Pathology Dose-response Relationship, Drug Interleukin-6 Blood Leukocyte Count Male Nitric Oxide Peroxidase Rats Respiratory Burst Time Factors Tumor Necrosis Factor-alpha Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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