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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Xi Ma, Shi-wei Ma, Xiao-ming Xu, Yuan-jing Tang, Nai-jun |
| Description | Country affiliation: China Author Affiliation: Chen X ( Department of Occupational Health, School of Public Health, Tianjin Medical University, Qixiangtai Road No. 22, Heping District, Tianjin 300070, China.) |
| Abstract | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine disruptors. To investigate peptide changes in the sera of rats chronically exposed to TCDD and to explore the association of these changes with liver morphology, TCDD was administrated to male rats at doses of 140, 350, and 875 ng/kg/week for 29 weeks. Serum was collected and proteomic analysis was performed using automated Bruker Daltonics ClinProt with matrix-assisted laser desorption/ionization time-of-flight mass spectrometer. One peptide at 1740.89 was found to be significantly decreased and further identified with nano LC-MS/MS system. The MS BLAST homology search engine reported the peptide to be a partial sequence of fibrinopeptide A. Liver fatty degeneration and necrosis were assessed by hematoxylin and eosin staining. Liver fatty degeneration and necrosis were both found to be significantly increased after TCDD exposure. Levels of fibrinopeptide A were significantly correlated with liver fatty degeneration and necrosis. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 2 |
| Volume Number | 33 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Drug-induced Liver Injury Etiology Endocrine Disruptors Toxicity Fatty Liver Chemically Induced Fibrinopeptide A Metabolism Liver Drug Effects Animals Biological Markers Blood Pathology Chromatography, Liquid Administration & Dosage Male Necrosis Proteomics Methods Rats Rats, Sprague-dawley Spectrometry, Mass, Matrix-assisted Laser Desorption-ionization Staining And Labeling Tandem Mass Spectrometry Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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