NDLI: Differential expression of the main polycyclic aromatic hydrocarbon responsive genes in the extrahepatic tissues of mice.

Please wait, while we are loading the content...

Year: 2017 Volume: 51

Year: 2017 Volume: 50

Year: 2017 Volume: 49

Year: 2016 Volume: 49

Year: 2016 Volume: 48

Year: 2016 Volume: 47

Year: 2016 Volume: 46

Year: 2016 Volume: 45

Year: 2016 Volume: 44

Year: 2016 Volume: 43

Year: 2016 Volume: 42

Year: 2016 Volume: 41

Year: 2015 Volume: 40

Year: 2015 Volume: 39

Year: 2014 Volume: 38

Year: 2014 Volume: 37

Year: 2014 Volume: 37 Issue: 3

Year: 2014 Volume: 37 Issue: 2

Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine.

Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): association with P-glycoprotein expression and location within tissues.

Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats.

A physiologically based toxicokinetic and toxicodynamic model links the tissue distribution of benzo[a]pyrene and toxic effects in the scallop Chlamys farreri.

Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis.

Antioxidant responses in Carassius auratus and Lolium perenne exposed to the laboratory pollution.

Semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1 protects against gamma radiation-induced oxidative stress.

Molecular cloning and expression of the gene for G protein alpha subunit induced by bisphenol A in marine polychaete Perinereis aibuhitensis.

Polychlorinated biphenyls and organochlorine pesticides in human milk samples from two regions in Croatia.

Triclocarban-induced change in intracellular Ca²âº level in rat thymocytes: cytometric analysis with Fluo-3 under Zn²âº-free conditions.

Chemical composition and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching.

Toxic effects of zearalenone on oxidative stress, inflammatory cytokines, biochemical and pathological changes induced by this toxin in the kidney of pregnant rats.

Studies on the effect of sodium arsenate on the enzymes of carbohydrate metabolism, brush border membrane, and oxidative stress in the rat kidney.

Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway.

Effects of cigarette smoke on Holter ECG recordings in patients with arterial hypertension. Part 2: Parameters of heart rate turbulence.

First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa).

Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring.

Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers.

Clinical features and treatment experience: a review of 292 Chinese cobra snakebites.

Effects of fullerene C60 nanoparticles on A549 cells.

Effects of nonylphenol exposure on expression of cell receptors and secretory function in mouse Sertoli TM4 cells.

Therapeutic potential of morin against liver fibrosis in rats: modulation of oxidative stress, cytokine production and nuclear factor kappa B.

Effect of cadmium on the extracellular Naâº, Kâº, and Ca²âº in the gill and small intestine of goldfish Carassius auratus.

Protective effects of seahorse extracts in a rat castration and testosterone-induced benign prostatic hyperplasia model and mouse oligospermatism model.

Combined effects of oxytetracycline and Pb on earthworm Eisenia fetida.

Effects of n-butylparaben on steroidogenesis and spermatogenesis through changed E2 levels in male rat offspring.

Andrographolide sodium bisulfate-induced apoptosis and autophagy in human proximal tubular endothelial cells is a ROS-mediated pathway.

Zn(II)-curcumin protects against hemorheological alterations, oxidative stress and liver injury in a rat model of acute alcoholism.

Toxicity assessment of environmental pollutant phenanthrene in clam Venerupis philippinarum using oxidative stress biomarkers.

Bisphenol A--sources, toxicity and biotransformation.

Biomonitorization of chromium, copper, iron, manganese and nickel in scalp hair from orthodontic patients by atomic absorption spectrometry.

Protective mechanisms of coenzyme-Q10 may involve up-regulation of testicular P-glycoprotein in doxorubicin-induced toxicity.

Exposure of mice to atrazine and its metabolite diaminochlorotriazine elicits oxidative stress and endocrine disruption.

Betaine supplementation protects against renal injury induced by cadmium intoxication in rats: role of oxidative stress and caspase-3.

Tributyltin induces a G2/M cell cycle arrest in human amniotic cells via PP2A inhibition-mediated inactivation of the ERK1/2 cascades.

Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid.

Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis.

Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells.

Intake of anthocyanidins pelargonidin and cyanidin reduces genotoxic stress in mice induced by diepoxybutane, urethane and endogenous nitrosation.

Metabolomic analysis revealed that female mussel Mytilus galloprovincialis was sensitive to bisphenol A exposures.

Consequences of tributyltin chloride induced stress in Leydig cells: an ex-vivo approach.

Tissue-specific induction of oxidative stress in goldfish by 2,4-dichlorophenoxyacetic acid: mild in brain and moderate in liver and kidney.

Study of the interaction between mercury (II) and bovine serum albumin by spectroscopic methods.

'Permethrin chronic exposure alters motor coordination in rats: effect of calcium supplementation and amlodipine'.

Differential expression of the main polycyclic aromatic hydrocarbon responsive genes in the extrahepatic tissues of mice.

Year: 2014 Volume: 37 Issue: 1

Year: 2013 Volume: 36

Year: 2013 Volume: 35

Year: 2012 Volume: 34

Year: 2012 Volume: 33

Year: 2011 Volume: 32

Year: 2011 Volume: 31

Year: 2010 Volume: 30

Year: 2010 Volume: 29

Year: 2009 Volume: 28

Year: 2009 Volume: 27

Year: 2008 Volume: 26

Year: 2008 Volume: 25

Year: 2007 Volume: 24

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Year: 2006 Volume: 21

Year: 2005 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2004 Volume: 17

Year: 2004 Volume: 16

Year: 2004 Volume: 15

Year: 2003 Volume: 15

Year: 2003 Volume: 14

Year: 2003 Volume: 13

Year: 1996 Volume: 2

Year: 1996 Volume: 1

Differential expression of the main polycyclic aromatic hydrocarbon responsive genes in the extrahepatic tissues of mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miao, Wenyu Jin, Yuanxiang Lin, Xiaojian Fu, Zhengwei
Description	Country affiliation: China Author Affiliation: Miao W ( College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China.); Jin Y ( College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China.); Lin X ( College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China.); Fu Z ( College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address: azwfu@zjut.edu.cn.)
Abstract	UNLABELLED: The hepatic toxic effects, including carcinogenicity and oxidative stress, of polycyclic aromatic hydrocarbons (PAHs) have been extensively studied in recent years. Previous reports have demonstrated that 3-methylcholanthrene (3MC) is capable of altering the expression of aryl hydrocarbon receptor (AHR)-regulated genes and antioxidant genes in liver, but little is known about the expression patterns in other tissues. To investigate whether similar effects could occur in the extrahepatic tissues, adult male ICR mice were received an intraperitoneal injection of 100 mg/kg 3MC and then analyzed after 6 and 24 h. We observed that the constitutive expression of AHR- and antioxidant-related genes was in a tissue-specific manner. Moreover, acute 3MC exposure significantly increased the mRNA levels of Cyp1a1 and Cyp1b1 in all the lung, kidney and heart. As to antioxidant genes, 3MC induced the transcription of glutathione reductase (Gr) in the lung and kidney at 24 h and the transcription of glutathione peroxidase 1 (Gpx1) in the lung and kidney at 6 and 24 h. Glutathione-S-transferase A1 (Gsta1) was significantly reduced in the kidney at 24 h, while no effect was observed in the lung and heart. The mRNA levels of NAD(P)H: quinone oxidoreductase 1 (Nqo1) were induced by 3MC in all the lung, kidney and heart. Although the constitutive expression of catalase (Cat) is very low in the heart, the transcription of Cat was significantly induced both at 6 and 24 h. No significant alternation in the transcription of glutathione synthetase (Gss), heme oxygenase 1 (Ho-1) and superoxide dismutase 1 (Sod1) was observed in all tissues. Taken together, ours findings suggested that the expression of AHR- and antioxidant-related genes in a tissue-specific manner with or without treatment of a PAH.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Environmental Pollutants Toxicity Gene Expression Drug Effects Kidney Lung Methylcholanthrene Myocardium Metabolism Animals Catalase Genetics Cytochrome P-450 Cyp1a1 Cytochrome P-450 Cyp1b1 Glutathione Peroxidase Glutathione Reductase Glutathione Synthase Glutathione Transferase Glyceraldehyde-3-phosphate Dehydrogenase (phosphorylating) Heme Oxygenase-1 Isoenzymes Male Membrane Proteins Mice, Inbred Icr Nad(p)h Dehydrogenase (quinone) Rna, Messenger Real-time Polymerase Chain Reaction Receptors, Aryl Hydrocarbon Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in