NDLI: Triclocarban-induced change in intracellular Ca²âº level in rat thymocytes: cytometric analysis with Fluo-3 under Zn²âº-free conditions.

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Triclocarban-induced change in intracellular Ca²âº level in rat thymocytes: cytometric analysis with Fluo-3 under Zn²âº-free conditions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miura, Yukari Chen, Xiaohui Yamada, Saki Sugihara, Aya Enkhjargal, Molomjamts Sun, Yuanzhi Kuroda, Keiko Satoh, Masaya Oyama, Yasuo
Description	Country affiliation: Japan Author Affiliation: Miura Y ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Chen X ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Yamada S ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Sugihara A ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Enkhjargal M ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Sun Y ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Kuroda K ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Satoh M ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.); Oyama Y ( Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan. Electronic address: oyama@ias.tokushima-u.ac.jp.)
Abstract	Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca(2+) concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca(2+). TCC at concentrations ranging from 0.1 µM to 3 µM increased intracellular Ca(2+) concentration biphasically: first by releasing Ca(2+) from intracellular Ca(2+) stores and then inducing Ca(2+) influx through store-operated Ca(2+) channels. The threshold TCC concentration to increase intracellular Ca(2+) concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca(2+) signaling in human lymphocytes.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Anti-infective Agents, Local Toxicity Calcium Metabolism Carbanilides Thymocytes Drug Effects Water Pollutants, Chemical Aniline Compounds Animals Cells, Cultured Fluorescent Dyes Male Rats Xanthenes Zinc Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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