NDLI: Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway.

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Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway.

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Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Park, Hanbyeol Yoo, Jong-Su Kim, Ji-Young Hwang, Bang Yeon Han, Jung-Soo Yeon, Seung-Woo Kang, Jae-Hoon
Description	Author Affiliation: Park H ( ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea.); Yoo JS ( ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea.); Kim JY ( ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea.); Hwang BY ( College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.); Han JS ( Department of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.); Yeon SW ( ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea. Electronic address: swyeon@ildong.com.); Kang JH ( ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea.)
Abstract	Amyloid beta (Aß) peptides, which are generated from amyloid precursor protein (APP), are thought to play a major role in the pathogenesis of Alzheimer's disease (AD). This study investigated the anti-amyloidogenic effects of the ethanolic extract of Meliae Fructus (ID1201) using human embryonic kidney 293 cells with stably expressed human wild-type or Swedish mutant APP695 and ß-secretase 1. ID1201 treatment enhanced the non-amyloidogenic metabolism of APP; increases in soluble APP levels and decreases in soluble APPß and Aß levels resulted from the -secretase activation through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. In addition, ID1201-treated 5×familial AD (FAD) mice with 5 mutations in APP and presenilin 1 showed reduced levels of Aß and amyloid plaques in the brain relative to those of 5×FAD mice with vehicle treatments. These results indicate that ID1201 possesses anti-amyloidogenic effects via the activation of the PI3K/Akt pathway, suggesting that it is a potential therapeutic agent for AD.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Amyloid Beta-peptides Metabolism Brain Drug Effects Melia Neuroprotective Agents Pharmacology Plant Extracts Amyloid Precursor Protein Secretases Genetics Animals Aspartic Acid Endopeptidases Cell Line Ethanol Chemistry Fruit Humans Mice, Transgenic Phosphatidylinositol 3-kinase Presenilin-1 Proto-oncogene Proteins C-akt Signal Transduction Solvents Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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