NDLI: Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring.

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Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring.

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Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mohammadipour, Abbas Fazel, Alireza Haghir, Hossein Motejaded, Fatemeh Rafatpanah, Houshang Zabihi, Hoda Hosseini, Mahmoud Bideskan, Alireza Ebrahimzadeh
Description	Country affiliation: Iran Author Affiliation: Mohammadipour A ( Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Fazel A ( Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Haghir H ( Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran); Motejaded F ( Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Rafatpanah H ( Immunology Research Center, Buali Institute, Mashhad University of Medical Sciences, Mashhad, Iran.); Zabihi H ( Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.); Hosseini M ( Neurocognitive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.); Bideskan AE ( Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: EbrahimzadehBA@mums.ac.ir.)
Abstract	Titanium dioxide nanoparticles (TiO2-NPs) are massively produced in the environment, and because of their wide usage, they are a potential risk of damage to human health. TiO2-NPs are often used as additives for paints, papers, and foods. The central nervous system (CNS), including hippocampal regions, is potentially susceptible targets for TiO2-NPs. This study aimed to determine the effects of exposure to TiO2-NPs during pregnancy on hippocampal cell proliferation and the learning and memory of offspring. Pregnant Wistar rats received intragastric TiO2-NPs (100 mg/kg body weight) daily from gestational day (GD) 2 to (GD) 21. Animals in the control group received the same volume of distilled water via gavage. After delivery, the one-day-old neonates were deeply anesthetized and weighed. They were then killed and the brains of each group were collected. Sections of the brains from the rat offspring were stained using Ki-67 immunolabeling and the immunohistochemistry technique. Some of the male offspring (n=12 for each group) were weaned at postnatal day (PND21), and housed until adulthood (PND60). Then the learning and memory in animals of each group were evaluated using passive avoidance and Morris water maze tests. The immunolabeling of Ki-67 protein as a proliferating cell marker showed that TiO2-NPs significantly reduced cell proliferation in the hippocampus of the offspring (P<0.05). Moreover, both the Morris water maze test and the passive avoidance test showed that exposure to TiO2-NPs significantly impaired learning and memory in offspring (P<0.05). These results may provide basic experimental evidence for a better understanding of the neurotoxic effects of TiO2-NPs on neonatal and adult brains.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Hippocampus Drug Effects Memory Metal Nanoparticles Toxicity Prenatal Exposure Delayed Effects Titanium Animals Avoidance Learning Cell Proliferation Female Cytology Metabolism Maternal-fetal Exchange Maze Learning Pregnancy Rats, Wistar Pharmacokinetics Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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