NDLI: Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid.

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Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid.

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Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Nai-sheng Li, Hong-ye Liu, Jie-sheng Yang, Wei-dong
Description	Country affiliation: Netherlands Author Affiliation: Zhang NS ( College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China); Li HY ( College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China); Liu JS ( College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China); Yang WD ( College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China)
Abstract	Okadaic acid (OA), a main component of diarrheic shellfish poisoning (DSP) toxins, is a strong and specific inhibitor of the serine/threonine protein phosphatases PP1 and PP2A. However, not all of the OA-induced effects can be explained by this phosphatase inhibition, and controversial results on OA are increasing. To provide clues on potential mechanisms of OA other than phosphatase inhibition, here, acute toxicity of OA was evaluated in zebrafish, and changes in gene expression in zebrafish liver tissues upon exposure to OA were observed by microarray. The i.p. ED50 (6 h) of OA on zebrafish was 1.54 µg OA/g body weight (bw). Among the genes analyzed on the zebrafish array, 55 genes were significantly up-regulated and 36 down-regulated in the fish liver tissue upon exposure to 0.176 µg OA/g bw (low-dose group, LD) compared with the low ethanol control (LE). However, there were no obvious functional clusters for them. On the contrary, fish exposure to 1.760 µg OA/g bw (high-dose group, HD) yielded a great number of differential expressed genes (700 up and 285 down) compared with high ethanol control (HE), which clustered in several functional terms such as p53 signaling pathway, Wnt signaling pathway, glutathione metabolism and protein processing in endoplasmic reticulum, etc. These genes were involved in protein phosphatase activity, translation factor activity, heat shock protein binding, as well as transmembrane transporter activity. Our findings may give some useful information on the pathways of OA-induced injury in fish.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Gene Expression Drug Effects Okadaic Acid Toxicity Zebrafish Genetics Animals Gene Expression Profiling Liver Metabolism Oligonucleotide Array Sequence Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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