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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Martinovic-Weigelt, Dalma Wang, Rong-Lin Villeneuve, Daniel L. Bencic, David C. Lazorchak, Jim Ankley, Gerald T. |
| Description | Country affiliation: United States Author Affiliation: Martinovic-Weigelt D ( US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USA. dalma@stthomas.edu) |
| Abstract | The studies presented in this manuscript focus on characterization of transcriptomic responses to anti-androgens in zebrafish (Danio rerio). Research on the effects of anti-androgens in fish has been characterized by a heavy reliance on apical endpoints, and molecular mechanisms of action (MOA) of anti-androgens remain poorly elucidated. In the present study, we examined effects of a short term exposure (24-96h) to the androgen receptor antagonists flutamide (FLU) and vinclozolin (VZ) on gene expression in gonads of sexually mature zebrafish, using commercially available zebrafish oligonucleotide microarrays (4×44K platform). We found that VZ and FLU potentially impact reproductive processes via multiple pathways related to steroidogenesis, spermatogenesis, and fertilization. Observed changes in gene expression often were shared by VZ and FLU, as demonstrated by overlap in differentially-expressed genes and enrichment of several common key pathways including: (1) integrin and actin signaling, (2) nuclear receptor 5A1 signaling, (3) fibroblast growth factor receptor signaling, (4) polyamine synthesis, and (5) androgen synthesis. This information should prove useful to elucidating specific mechanisms of reproductive effects of anti-androgens in fish, as well as developing biomarkers for this important class of endocrine-active chemicals. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Issue Number | 2 |
| Volume Number | 101 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-25 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Androgen Receptor Antagonists Pharmacology Flutamide Gene Expression Drug Effects Ovary Oxazoles Testis Zebrafish Genetics Animals Female Fertilization Gene Expression Profiling Male Oligonucleotide Array Sequence Analysis Metabolism Receptors, Androgen Reproduction Signal Transduction Spermatogenesis Steroids Biosynthesis Water Pollutants, Chemical Toxicity Physiology Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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