NDLI: Aniline exposure associated with up-regulated transcriptional responses of three glutathione S-transferase Delta genes in Drosophila melanogaster.

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Aniline exposure associated with up-regulated transcriptional responses of three glutathione S-transferase Delta genes in Drosophila melanogaster.

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Aniline exposure associated with up-regulated transcriptional responses of three glutathione S-transferase Delta genes in Drosophila melanogaster.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chan, Wen-Chiao Chien, Yi-Chih Chien, Cheng-I
Description	Country affiliation: Taiwan Author Affiliation: Chan WC ( Department of Biology, National Changhua University of Education, Changhua 500, Taiwan.); Chien YC ( Department of Biology, National Changhua University of Education, Changhua 500, Taiwan.); Chien CI ( Department of Environmental Engineering and Science, Feng Chia University, Taichung 407, Taiwan. Electronic address: cichien@fcu.edu.tw.)
Abstract	Complex transcriptional profile of glutathione S-transferase Delta cluster genes occurred in the developmental process of the fruit fly Drosophila melanogaster. The purpose of this project was to quantify the expression levels of Gst Delta class genes altered by aniline exposure and to understand the relationship between aniline dosages and the variation of Gst Delta genes expressed in D. melanogaster. Using RT-PCR expression assays, the expression patterns of the transcript mRNAs of the glutathione S-transferase Delta genes were revealed and their expression levels were measured at eggs, larvae, pupae and adults. The adult stage was selected for further dose-response assays. After analysis, the results indicated that three Gst Delta genes (Gst D2, Gst D5 and Gst D6) were found to show a peak of up-regulated transcriptional response at 6-8h of exposure of aniline. Furthermore, the dose-response relationship of their induction levels within the dose regiments (from 1.2 to 2.0 µl/tube) had been measured. The expression patterns and annotations of these genes were discussed in the context.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Aniline Compounds Toxicity Drosophila Melanogaster Drug Effects Glutathione Transferase Genetics Insect Proteins Animals Rna, Messenger Metabolism Transcription, Genetic Up-regulation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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