NDLI: Poly(vinyl alcohol)-coated silver nanoparticles: activation of neutrophils and nanotoxicology effects in human hepatocarcinoma and mononuclear cells.

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Poly(vinyl alcohol)-coated silver nanoparticles: activation of neutrophils and nanotoxicology effects in human hepatocarcinoma and mononuclear cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Paino, Iêda Maria Martinez Zucolotto, Valtencir
Description	Author Affiliation: Paino IM ( Nanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, University of São Paulo, Av. Trab. São Carlense, 400, CEP13566-590 São Carlos, SP, Brazil. Electronic address: iedammp@hotmail.com.); Zucolotto V ( Nanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, University of São Paulo, Av. Trab. São Carlense, 400, CEP13566-590 São Carlos, SP, Brazil.)
Abstract	Silver nanoparticles (AgNps) have been described as important for their excellent biocompatibility, biomedical applications. Nevertheless, AgNps can interact with the immune system which is essential to analyze human exposure to assess their potential risk to health and environment. In general, the primary site for accumulation of nanoparticles has been demonstrated to be the liver. Furthermore, the direct activation of neutrophils or oxidative burst by a given nanoparticle is poorly documented. In this paper, we investigated the cell uptake, apoptosis, necrosis, DNA damage in human hepatocarcinoma cells (HepG2), primary normal human peripheral blood mononuclear cells (PBMC) and the direct activation of primary isolated neutrophils through the oxidative burst on exposure to AgNps coated with Polyvinyl-alcohol (PVA). All cell types were incubated in the presence of 1.0 and 50.0 µM of AgNps-PVA for 24h. A significant cyto- and genotoxic-response and the activation of human neutrophils were induced by AgNps-PVA (p<0.05). Our results revealed that AgNps can interact with the normal isolated neutrophils, PBMC and HepG2 cells in vitro, which opens the way for further studies on the toxicological effects of AgNps in the human immune system response and cancer cells.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Leukocytes, Mononuclear Drug Effects Metal Nanoparticles Toxicity Neutrophils Polyvinyl Alcohol Silver Apoptosis Carcinoma, Hepatocellular Cells, Cultured Dna Damage Female Hep G2 Cells Humans Metabolism Liver Neoplasms Male Chemistry Ultrastructure Microscopy, Electron, Transmission Necrosis Chemically Induced Reactive Oxygen Species Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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