NDLI: Esculetin induces death of human colon cancer cells via the reactive oxygen species-mediated mitochondrial apoptosis pathway.

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Esculetin induces death of human colon cancer cells via the reactive oxygen species-mediated mitochondrial apoptosis pathway.

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Esculetin induces death of human colon cancer cells via the reactive oxygen species-mediated mitochondrial apoptosis pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Areum Daseul Han, Xia Piao, Mei Jing Hewage, Susara Ruwan Kumara Madduma Hyun, Chang Lim Cho, Suk Ju Hyun, Jin Won
Description	Author Affiliation: Kim AD ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.); Han X ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.); Piao MJ ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.); Hewage SR ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.); Hyun CL ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.); Cho SJ ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address: sukjucho@gmail.com.); Hyun JW ( School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address: jinwonh@jejunu.ac.kr.)
Abstract	The present study investigated the apoptotic effects of esculetin, a coumarin derivative, on the human colon cancer cell line HT-29. Esculetin had cytotoxic effects on HT-29 cells in a dose- and time-dependent manner; treatment with 55 µg/mL esculetin reduced cell viability by 50%. Esculetin induced apoptosis, as evidenced by apoptotic body formation, an increased percentage of cells in sub-G1 phase, and DNA fragmentation. Moreover, esculetin increased mitochondrial membrane depolarization, released cytochrome c into cytosol, and modulated the expression of apoptosis-associated proteins, resulting in reduced expression of B cell lymphoma-2, increased expression of Bcl-2-associated X protein, and activation of caspase-9 and caspase-3. Esculetin induced the formation of reactive oxygen species; however, treatment with an antioxidant reduced the apoptotic cell death induced by esculetin treatment. In addition, esculetin activated mitogen-activated protein kinases and specific inhibitors of these kinases abrogated the reduction in cell viability induced by esculetin treatment.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	39
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Antineoplastic Agents Pharmacology Colonic Neoplasms Metabolism Reactive Oxygen Species Umbelliferones Apoptosis Drug Effects Caspase 3 Caspase 9 Dna Fragmentation Ht29 Cells Humans Membrane Potential, Mitochondrial Mitochondria Mitogen-activated Protein Kinases Proto-oncogene Proteins C-bcl-2 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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