NDLI: Blocking TGF-ß expression inhibits silica particle-induced epithelial-mesenchymal transition in human lung epithelial cells.

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Blocking TGF-ß expression inhibits silica particle-induced epithelial-mesenchymal transition in human lung epithelial cells.

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Blocking TGF-ß expression inhibits silica particle-induced epithelial-mesenchymal transition in human lung epithelial cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rong, Yi Shen, Yan Zhang, Zhihong Cui, Xiuqing Xiao, Lili Liu, Yuewei Luo, Xin Chen, Weihong
Description	Author Affiliation: Rong Y ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China); Shen Y ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China); Zhang Z ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China); Cui X ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China); Xiao L ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China); Liu Y ( Institute of Health Surveillance, Analysis and Protection, Hubei Center for Disease Control and Prevention, Wuhan 430070, Hubei, China.); Luo X ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China); Chen W ( Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China)
Abstract	The main characteristic of silicosis is irreversible fibrosis. Certain studies have shown that epithelial-mesenchymal transition (EMT) regulated by transforming growth factor-ß (TGF-ß) is involved in fibrosis. Thus, we suggest that TGF-ß regulated EMT may play an important role in silicosis. In this study, we determined the expression of TGF-ß-Smad2/3, EMT- and ECM-related markers in lung epithelial cells treated with silica particle by RT-PCR, western-blot and ELISA. In order to explore the role of TGF-ß, we used TGF-ß inhibitor in the cell model. We found that the cells lost the expression of epithelial phenotypic markers and acquired increased expression of mesenchymal cells markers with ECM deposition after treatment with silica particle. Moreover, the changes of EMT-related event was restricted in response to TGF-ß inhibitor. These findings suggest that EMT is essentially involved in the pathogenesis of fibrosis induced by silica particles and down-regulating the TGF-ß expression can inhibit the process of EMT.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	40
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Epithelial Cells Drug Effects Epithelial-mesenchymal Transition Pyrazoles Pharmacology Quinolines Silicon Dioxide Toxicity Transforming Growth Factor Beta Genetics Cell Line Cell Proliferation Cytology Metabolism Extracellular Matrix Proteins Gene Expression Regulation Humans Smad2 Protein Smad3 Protein Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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