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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dehghan, Firouzeh Yusof, Ashril Muniandy, Sekaran Salleh, Naguib |
| Description | Author Affiliation: Dehghan F ( Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia); Yusof A ( Department of Exercise Science, Sports Centre, University of Malaya, Kuala Lumpur, Malaysia.); Muniandy S ( Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.); Salleh N ( Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: naguib.salleh@yahoo.com.) |
| Abstract | PURPOSE: The high risk of knee injuries in female may be associated with sex-steroid hormone fluctuations during the menstrual cycle by its effect on ligaments and tendons stiffness. This study examined changes in knee range of motion in presence of estrogen and progesterone and investigated the interaction of their antagonists to relaxin receptors. METHOD: Sixty WKY rats were divided into 10 different groups receiving 17ß-estradiol (0.2, 2, 20 and 50 µg/kg), progesterone (4 mg/kg), estrogen receptor (ER) antagonist ICI 182/780, ERß antagonist PHTPP, ER antagonist MPP, and mifepristone in presence of estrogen and progesterone. Physiologic dose were injected subcutaneously 30 min before of hormone injection for 3 days consequently. Sham group received peanut oil (vehicle) also for 3 consecutive days. Following the treatment administrations, the knee range of motion and RXFP1/RXFP2 mRNA and protein expression were examined in the patellar tendon, lateral collateral ligament, and hamstring muscle. RESULTS: Our data showed that the knee range of motion was significantly increased in progesterone and high doses estrogen treatment but not significantly increased in low doses of estrogen treatment. The range of motion was decreased in the presence of estrogen receptor (ER) antagonist ICI 182/780, ERß antagonist PHTPP, ER antagonist MPP, and mifepristone, independently. CONCLUSION: Progesterone and high doses of estrogen treatment resulted in the highest range of knee laxity correlated to expression of both relaxin receptor isoforms in knee tissues. Our findings thus suggested that female subjects are more vulnerable toward non-traumatic knee injury due to estrogen and progesterone fluctuation as compared to male subjects. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Hindlimb Drug Effects Range Of Motion, Articular Receptors, G-protein-coupled Genetics Receptors, Peptide Steroids Administration & Dosage Animals Estradiol Analogs & Derivatives Pharmacology Female Physiology Male Mifepristone Piperidines Progesterone Pyrazoles Pyrimidines Rats Rats, Inbred Wky Metabolism Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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