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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdul, Khaja Shameem Mohammed Jayasinghe, Sudheera Sammanthi Chandana, Ediriweera P. S. Jayasumana, Channa De Silva, P. Mangala C. S. |
| Description | Author Affiliation: Abdul KS ( Department of Zoology, Faculty of Science, University of Ruhuna, Matara 81000, Sri Lanka. Electronic address: khajashameem@zoo.ruh.ac.lk.); Jayasinghe SS ( Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.); Chandana EP ( Department of Zoology, Faculty of Science, University of Ruhuna, Matara 81000, Sri Lanka.); Jayasumana C ( Department of Pharmacology, Faculty of Medicine, Rajarata University, Anuradhapura 50008, Sri Lanka.); De Silva PM ( Department of Zoology, Faculty of Science, University of Ruhuna, Matara 81000, Sri Lanka.) |
| Abstract | Arsenic (As) is ubiquitous in nature and humans being exposed to arsenic via atmospheric air, ground water and food sources are certain. Major sources of arsenic contamination could be either through geological or via anthropogenic activities. In physiological individuals, organ system is described as group of organs that transact collectively and associate with other systems for conventional body functions. Arsenic has been associated with persuading a variety of complications in body organ systems: integumentary, nervous, respiratory, cardiovascular, hematopoietic, immune, endocrine, hepatic, renal, reproductive system and development. In this review, we outline the effects of arsenic on the human body with a main focus on assorted organ systems with respective disease conditions. Additionally, underlying mechanisms of disease development in each organ system due to arsenic have also been explored. Strikingly, arsenic has been able to induce epigenetic changes (in utero) and genetic mutations (a leading cause of cancer) in the body. Occurrence of various arsenic induced health effects involving emerging areas such as epigenetics and cancer along with their respective mechanisms are also briefly discussed. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Arsenic Toxicity Epigenesis, Genetic Drug Effects Mutation Cardiovascular Diseases Chemically Induced Environmental Exposure Hematologic Diseases Humans Immune System Diseases Neoplasms Genetics Nervous System Diseases Respiratory Tract Diseases Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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