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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alamolhodaei, Nafiseh Sadat Shirani, Kobra Karimi, Gholamreza |
| Description | Author Affiliation: Alamolhodaei NS ( School of Pharmacy, Mashhad University of Medical Sciences, Iran. Electronic address: alamolhodaein921@mums.ac.ir.); Shirani K ( Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: shiranik911@mums.ac.ir.); Karimi G ( Pharmaceutical Research Center and Pharmacy School, Mashhad University of Medical Sciences, Iran. Electronic address: karimig@mums.ac.ir.) |
| Abstract | Arsenic, a naturally ubiquitous element, is found in foods and environment. Cardiac dysfunction is one of the major causes of morbidity and mortality in the world. Arsenic exposure is associated with various cardiopathologic effects including ischemia, arrhythmia and heart failure. Possible mechanisms of arsenic cardiotoxicity include oxidative stress, DNA fragmentation, apoptosis and functional changes of ion channels. Several evidences have shown that mitochondrial disruption, caspase activation, MAPK signaling and p53 are the pathways for arsenic induced apoptosis. Arsenic trioxide is an effective and potent antitumor agent used in patients with acute promyelocytic leukemia and produces dramatic remissions. As2O3 administration has major limitations such as T wave changes, QT prolongation and sudden death in humans. In this review, we discuss the underlying pathobiology of arsenic cardiotoxicity and provide information about cardiac health effects associated with some medicinal plants in arsenic toxicity. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Arrhythmias, Cardiac Chemically Induced Arsenic Toxicity Heart Failure Myocardial Infarction Animals Apoptosis Drug Effects Cardiotoxicity Gene Expression Regulation Humans Mitochondria Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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