NDLI: Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Namgoong, Suhg Cheong, Hyun Sub Kim, Ji On Kim, Lyoung Hyo Na, Han Sung Koh, In Song Chung, Myeon Woo Shin, Hyoung Doo
Spatial Coverage	United States Republic of Korea
Description	Author Affiliation: Namgoong S ( Department of Life Science, Sogang University, Seoul, Republic of Korea); Cheong HS ( Research Institute for Basic Science, Sogang University, Seoul, Republic of Korea.); Kim JO ( Department of Life Science, Sogang University, Seoul, Republic of Korea); Kim LH ( Department of Life Science, Sogang University, Seoul, Republic of Korea); Na HS ( Clinical Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex, Osong, Chungcheongbuk-do, Republic of Korea.); Koh IS ( Department of Physiology, College of Medicine, Hanyang University, Seoul, Republic of Korea.); Chung MW ( Clinical Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex, Osong, Chungcheongbuk-do, Republic of Korea. Electronic address: mwchung@korea.kr.); Shin HD ( Department of Life Science, Sogang University, Seoul, Republic of Korea)
Abstract	Organic anion-transporting polypeptide (OATP; gene symbol, SLCO) transporters are generally involved in the uptake of multiple drugs and their metabolites at most epithelial barriers. The pattern of single-nucleotide polymorphisms (SNPs) in these transporters may be determinants of interindividual variability in drug disposition and response. The objective of this study was to define the distribution of SNPs of three SLCO genes, SLCO1B1, SLCO1B3, and SLCO2B1, in a Korean population and other ethnic groups. The study was screened using the Illumina GoldenGate assay for genomic DNA from 450 interethnic subjects, including 11 pharmacogenetic core variants and 76 HapMap tagging SNPs. The genotype distribution of the Korean population was similar to East Asian populations, but significantly different from African American and European American cohorts. These interethnic differences will be useful information for prospective studies, including genetic association and pharmacogenetic studies of drug metabolism by SLCO families.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	40
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Ethnic Groups Genetics Organic Anion Transporters, Sodium-independent Organic Anion Transporters Polymorphism, Single Nucleotide African Americans Asian Americans European Continental Ancestry Group Genotype Humans Oligonucleotide Array Sequence Analysis Republic Of Korea Ethnology Organic Anion Transport Polypeptide C United States Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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