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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Jing-Zhe Wang, Zhu-Xin Ma, Li-Hui Shen, Xing-Bin Sun, Yu Hu, Da-Wei Sun, Li-Xin |
| Description | Country affiliation: China Author Affiliation: Yang JZ ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China.); Wang ZX ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China.); Ma LH ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China.); Shen XB ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China.); Sun Y ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China.); Hu DW ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China. Electronic address: dawei.hu@163.com.); Sun LX ( The Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Chengde 067000, Hebei, China. Electronic address: cyfyzys@163.com.) |
| Abstract | Investigation of organochlorine pesticides residues (important environmental contamination causing malignant transformation) in breast cancer patients is valuable to understanding their roles in breast cancer. 75 invasive ductal carcinoma (IDC) patients were enrolled with control of 79 benign breast diseases patients and control of 80 healthy women. Morning fasting blood specimens and adipose tissue specimens beside the primary lesion were detected with gas chromatograph. In blood specimens, both levels of ß-HCH and PCTA were higher in IDC than those in both controls (both p<0.05), and increasingly higher among the three IDC degrees. In adipose tissue specimens, all levels of ß-HCH, PCTA and pp'-DDE were higher in IDC than those in control (all p<0.05) and increasingly higher among three IDC degrees. The levels of ß-HCH, PCTA in both blood specimens and adipose tissue specimens were higher in estrogen receptor (ER) positive IDC than those in ER negative IDC (all p<0.05). The higher level of organochlorine pesticides residues in blood and adipose tissue specimens of IDC infers its association with IDC, but the details remains to reveal, and this study may helpful in this field. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Adipose Tissue Chemistry Breast Neoplasms Blood Carcinoma, Ductal, Breast Hydrocarbons, Chlorinated Toxicity Adult Aged Metabolism Pathology Chlorobenzenes Dichlorodiphenyl Dichloroethylene Female Humans Lindane Middle Aged Receptors, Estrogen Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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