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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Yang Jiang, Liping She, Yan Chen, Min Li, Qiujuan Yang, Guang Geng, Chengyan Tang, Liyun Zhong, Laifu Jiang, Lijie Liu, Xiaofang |
| Description | Author Affiliation: Yang Y ( Department of Nutrition and Food Safety, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China); Jiang L ( China-Japanese Joint Institute for Medical and Pharmaceutical Science, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China); She Y ( Department of Nutrition and Food Safety, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China); Chen M ( Department of Nutrition and Food Safety, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China.); Li Q ( Department of Nutrition and Food Safety, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China.); Yang G ( Department of Nutrition and Food Safety, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China.); Geng C ( China-Japanese Joint Institute for Medical and Pharmaceutical Science, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China); Tang L ( Department of Gynaecology and Obstetrics, The Second Hospital of Dalian Medical University, No. 467 of Zhongshan Road, Dalian 116011, Liaoning, PR China.); Zhong L ( China-Japanese Joint Institute for Medical and Pharmaceutical Science, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China); Jiang L ( Department of Internal Medicine, The Affiliated Zhong Shan Hospital of Dalian University, Dalian, Liaoning, PR China.); Liu X ( Department of Nutrition and Food Safety, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, Liaoning, PR China. Electronic address: food@dlmedu.edu.cn.) |
| Abstract | Olaquindox (OLA) is a potent antibacterial agent used as a feed additive and growth promoter. In this study, the genotoxic potential of OLA was investigated in the human embryonic kidney cell line 293 (HEK293). Results showed that OLA caused significant increases of DNA migration. Lysosomal membrane permeability and mitochondrial membrane potential were reduced after treatment with OLA. OLA was shown to induce ROS production and GSH depletion. The expression of p53 protein is increased in cells incubated with OLA. The activation of p53 and ATM gene was assessed by exposure to OLA. Furthermore, NAC reduced DNA migration, ROS formation, GSH depletion and the expression of the p53 protein and gene. And desipramine significantly decreased AO fluorescence intensity and the expression of the p53 protein and gene. These results support the assumption that OLA exerted genotoxic effects and induced DNA strand breaks in HEK293 cells, possibly through lysosomal-mitochondrial pathway involving ROS production and p53 activation. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Dna Drug Effects Lysosomes Mitochondria Quinoxalines Toxicity Tumor Suppressor Protein P53 Metabolism Cell Proliferation Dna Damage Gene Expression Regulation Hek293 Cells Humans Reactive Oxygen Species Signal Transduction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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