NDLI: SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians.

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SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sortica, Vinicius A. Fiegenbaum, Marilu Lima, Luciana O. Van der Sand, Cézar R. Van der Sand, Luis C. Ferreira, Maria E. W. Pires, Renan C. Hutz, Mara H.
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Sortica VA ( Departamento de Genética, Universidade Federal do RioGrande do Sul, Porto Alegre, Brazil.)
Abstract	BACKGROUND: Variants in uptake and efflux transporters can influence diverse statin pharmacokinetics in different populations. This study aimed to investigate the influence of SLCO1B1 gene polymorphism on simvastatin treatment efficacy in a Brazilian population of European ancestry. METHODS: Two hundred and sixteen hypercholesterolemic patients were treated with 20 mg/day simvastatin for 6 months. Plasma lipid and lipoprotein levels were measured at baseline and after 2 and 6 months of treatment. The single nucleotide polymorphisms (SNPs) c.388A>G, c.463C>A and c.521T>C at SLCO1B1 gene were determined by allelic discrimination with TaqMan 5'-nuclease assays. The 388G allele was observed in 160 patients, the 521 C allele was observed in 64 individuals, whereas 61 subjects were 463 A allele carriers. RESULTS: Carriers of the SLCO1B1 388G allele had a greater reduction of total cholesterol and LDL cholesterol with simvastatin treatment, when compared with 56 388A homozygotes (-28.8% vs. -15.8%, p=0.005 and -39.0% vs. -30.6%, p=0.003; respectively). The c.463C>A and c.521T>C SNPs were not associated with simvastatin treatment. The SLCO1B1 haplotypes showed no statistically significant differences in mean percentage reductions in lipid and lipoprotein levels after simvastatin treatment. CONCLUSIONS: The present study suggests that the SLCO1B1 c.388A>G polymorphism could play a role in the inter-individual variation of clinical response to simvastatin in Brazilians. These results add to those that suggest that the effects of SLCO1B1 variants may be statin specific.
File Format	HTM / HTML
ISSN	14346621
Issue Number	3
Volume Number	50
e-ISSN	14374331
Journal	Clinical Chemistry and Laboratory Medicine
Language	English
Publisher	Walter de Gruyter
Publisher Date	2012-03-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Haplotypes Research Support, Non-u.s. Gov't Anticholesteremic Agents Organic Anion Transport Polypeptide C Discipline Clinical chemistry Simvastatin Gene Frequency Humans Middle Aged European Continental Ancestry Group Male Treatment Outcome Pharmacology Hydroxymethylglutaryl-coa Reductase Inhibitors Therapeutic Use Journal Article Organic Anion Transporters Discipline Clinical Chemistry Brazil Genetics Female Polymorphism, Single Nucleotide
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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