NDLI: MicroRNA-203 contributes to skin re-epithelialization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Viticchiè, G. Lena, A. M. Cianfarani, F. Odorisio, T. Annicchiarico-Petruzzelli, M. Melino, G. Candi, E.
Description	Country affiliation: Italy Author Affiliation: Viticchiè G ( Department of Experimental Medicine and Surgery, University of Tor Vergata, Via Montpellier, 1, Rome 00133, Italy.)
Abstract	Keratinocyte proliferation and migration are crucial steps for the rapid closure of the epidermis during wound healing, but the molecular mechanisms involved in this cellular response remain to be completely elucidated. Here, by in situ hybridization we characterize the expression pattern of miR-203 after the induction of wound in mouse epidermis, showing that its expression is downregulated in the highly proliferating keratinocytes of the 'migrating tongue', whereas it is strongly expressed in the differentiating cells of the skin outside the wound. Furthermore, subcutaneous injections of antagomiR-203 in new born mice dorsal skin strengthened, in vivo, the inverse correlation between miR-203 expression and two new target mRNAs: RAN and RAPH1. Our data suggest that miR-203, by controlling the expression of target proteins that are responsible for both keratinocyte proliferation and migration, exerts a specific role in wound re-epithelialization and epidermal homeostasis re-establishment of injured skin.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2012.174
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-11-29
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Micrornas Research Support, Non-u.s. Gov't Re-epithelialization Gene Expression Regulation Epidermis Metabolism Ran Gtp-binding Protein Discipline Cell Biology Animals Genetics Skin Mice Injuries
Content Type	Text
Resource Type	Article

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