NDLI: The double life of MULE in preeclamptic and IUGR placentae

Please wait, while we are loading the content...

Year: 2017 Volume: 8

Year: 2016 Volume: 7

Year: 2016 Volume: 6

Year: 2015 Volume: 6

Year: 2014 Volume: 5

Year: 2013 Volume: 4

Year: 2012 Volume: 3

Role of the promyelocytic leukaemia protein in cell death regulation.

Cancer metabolism: current perspectives and future directions.

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.

Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis.

A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells.

Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.

ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity.

Involvement of $K_{v}1.3$ and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity

Altered dynamics of ubiquitin hybrid proteins during tumor cell apoptosis.

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.

Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer.

BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy.

Stem cell gene expression in MRPS18-2-immortalized rat embryonic fibroblasts.

Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells.

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway.

Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells

JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure.

The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome.

Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.

CLIPR-59 regulates TNF- -induced apoptosis by controlling ubiquitination of RIP1.

OMICS, a multidisciplinary friendship.

Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate.

mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons.

Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis.

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

Activation of the unfolded protein response enhances motor recovery after spinal cord injury.

Occludin is required for apoptosis when claudin-claudin interactions are disrupted.

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.

Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells.

Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis.

Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis

IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation.

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

Stabilization of ribozyme-like cis-noncoding rRNAs induces apoptotic and nonapoptotic death in lung cells

HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase.

Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.

FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice.

Regulation of p73 activity by post-translational modifications.

Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications

MicroRNA-34a upregulation during seizure-induced neuronal death.

Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays.

Decreased expression of the augmenter of liver regeneration results in increased apoptosis and oxidative damage in human-derived glioma cells.

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model.

PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing.

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein. (Part 1)

Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers.

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity.

Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.

Mss4 protein is a regulator of stress response and apoptosis.

Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth.

Resistance to ABT-737 in activated T lymphocytes: molecular mechanisms and reversibility by inhibition of the calcineurin-NFAT pathway.

LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation.

Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells.

TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.

Emerging concepts: linking hypoxic signaling and cancer metabolism.

Selective modulation of subtype III $IP_{3}R$ by Akt regulates ER $Ca^{2+}$ release and apoptosis

The double life of MULE in preeclamptic and IUGR placentae

Mitochondrial DNA: a proinflammatory 'enemy from within' during HIV infection?

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs.

Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors.

Inhibition of Bax protects neuronal cells from oligomeric Aß neurotoxicity.

Overexpression of Batf induces an apoptotic defect and an associated lymphoproliferative disorder in mice.

p57(KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect.

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2.

Preferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell death.

In vitro differentiation of mouse embryonic stem cells into inner ear hair cell-like cells using stromal cell conditioned medium.

Increased -synuclein phosphorylation and nitration in the aging primate substantia nigra.

LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes.

Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition

A novel role for RIP1 kinase in mediating TNF production.

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aß.

Acute hypoxia induces apoptosis of pancreatic ß-cell by activation of the unfolded protein response and upregulation of CHOP.

TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism.

Endothelial cells regulate p53-dependent apoptosis of neural progenitors after irradiation.

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry.

Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP.

NOXA as critical mediator for drug combinations in polychemotherapy.

Intrinsic regulation of hemangioma involution by platelet-derived growth factor.

Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.

Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress.

Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia.

Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis.

Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis

HtrA2 deficiency causes mitochondrial uncoupling through the $F_{1}F_{0}-ATP$ synthase and consequent ATP depletion

BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site.

Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress.

Caspase-1: is IL-1 just the tip of the ICEberg?

Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity

Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.

The ATF6 branch of unfolded protein response and apoptosis are activated to promote African swine fever virus infection.

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.

A $Lys49-PLA_{2}$ myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.

Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes.

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.

Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3.

14-3-3 protects against stress-induced apoptosis.

Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells.

Alpha-synuclein: from secretion to dysfunction and death.

Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors.

Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity.

Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.

Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity

Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

AMP-activated protein kinase- 1 as an activating kinase of TGF-ß-activated kinase 1 has a key role in inflammatory signals.

D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent.

BCLAF1 is a radiation-induced H2AX-interacting partner involved in Î³H2AX-mediated regulation of apoptosis and DNA repair.

MiR-30e and miR-181d control radial glia cell proliferation via HtrA1 modulation.

Bax inhibitor-1 is a novel IP3 receptor-interacting and -sensitizing protein.

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein. (Part 2)

The P2X7 receptor is a key modulator of aerobic glycolysis.

Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways.

Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak.

Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence.

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors.

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation

NHERF1/EBP50 controls lactation by establishing basal membrane polarity complexes with prolactin receptor.

TP53 PIN3 and PEX4 polymorphisms and infertility associated with endometriosis or with post-in vitro fertilization implantation failure.

Regulation of the tumor suppressor PTEN by SUMO.

Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation.

Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes).

CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.

Proliferation and tissue remodeling in cancer: the hallmarks revisited.

MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme.

Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics.

p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling.

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways.

DAMTC regulates cytoskeletal reorganization and cell motility in human lung adenocarcinoma cell line: an integrated proteomics and transcriptomics approach.

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation.

Bcl-2 family member Bcl-G is not a proapoptotic protein

Bcl-G acquitted of murder!

A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation.

A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFß-mediated apoptosis.

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells.

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor.

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure.

Mitosis-targeted anti-cancer therapies: where they stand.

BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1 stability and MGMT expression.

The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells.

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.

Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment.

Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis.

Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation.

Autophagy as a new therapeutic target in Duchenne muscular dystrophy.

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.

Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens.

Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme

ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction.

miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer.

Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death.

CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity

Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord.

Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival.

Dysregulation of core components of SCF complex in poly-glutamine disorders.

JNK2 is activated during ER stress and promotes cell survival.

JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry.

Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells.

ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells.

Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.

Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative $Ca^{2+}$ entry, mitochondrial perturbation and caspase overactivation

MicroRNA-203 contributes to skin re-epithelialization.

miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1.

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.

Tunneling-nanotube direction determination in neurons and astrocytes.

uPAR and cathepsin B shRNA impedes TGF-ß1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway.

Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells.

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage.

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3 /ß and Bax, leading to permeability transition pore opening and tumor cell death.

Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma.

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells.

TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner.

Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice.

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism.

Year: 2011 Volume: 2

Year: 2010 Volume: 1

The double life of MULE in preeclamptic and IUGR placentae

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rolfo, A. Garcia, J. Todros, T. Post, M. Caniggia, I.
Description	Country affiliation: Canada Author Affiliation: Rolfo A ( Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.)
Abstract	The E3 ubiquitin ligase MULE (Mcl-1 Ubiquitin Ligases E3) targets myeloid cell leukemia factor 1 (Mcl-1) and tumor suppressor p53 for proteasomal degradation. Although Mcl-1 and p53 have been implicated in trophoblast cell death in preeclampsia (PE) and intrauterine growth restriction (IUGR), the mechanisms regulating their expression in the human placenta remains elusive. Herein, we investigated MULE's involvement in regulating Mcl-1 and p53 degradation during normal and abnormal (PE, IUGR) placental development. MULE expression peaked at 5-7 weeks of gestation, when oxygen tension is low and inversely correlated with that of Mcl-1 and p53. MULE efficiently bound to Mcl-1 and p53 and regulated their ubiquitination during placental development. Exposure of first trimester villous explants to 3% O(2) resulted in elevated MULE expression compared with 20% O(2). Low-oxygen-induced MULE expression in JEG3 choriocarcinoma cells was abolished by hypoxia-inducible factor (HIF)-1 siRNA. MULE was overexpressed in both PE and IUGR placentae. In PE, MULE preferentially targeted p53 for degradation, allowing accumulation of pro-apoptotic Mcl-1 isoforms. In IUGR, however, MULE targeted pro-survival Mcl-1, allowing p53 to accumulate and exert its apoptotic function. These data demonstrate that oxygen regulates Mcl-1 and p53 stability during placentation via HIF-1-controlled MULE expression. The different preferential targets of MULE in PE and IUGR placentae classify early-onset PE and IUGR as distinct molecular pathologies.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2012.44
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-05-03
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, Non-u.s. Gov't Antagonists & Inhibitors Ubiquitination Hek293 Cells Tumor Suppressor Protein P53 Genetics Oxygen Hypoxia-inducible Factor 1, Alpha Subunit Placentation Rna, Small Interfering Fetal Growth Retardation Pre-eclampsia Metabolism Gestational Age Rna Interference Pregnancy Discipline Cell Biology Pathology Placenta Myeloid Cell Leukemia Sequence 1 Protein Cell Line, Tumor Proto-oncogene Proteins C-bcl-2 Ubiquitin-protein Ligases
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in