NDLI: Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells.

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Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells.

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Year: 2011 Volume: 2

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Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, C-H Kao, Y-H Huang, K-S Wang, C-Y Lin, L-W
Description	Country affiliation: Taiwan Author Affiliation: Yang CH ( Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan.)
Abstract	This study is the first report that investigated the apoptosis-inducing effects of Cordyceps militaris (CM) and its mycelial fermentation in human glioblastoma cells. Both fractions arrested the GBM8401 cells in the G0/G1 phase, whereas the U-87MG cells were arrested at the G2/M transitional stage. Western blot data suggested that upregulation of p53 and p21 might be involved in the disruption of cell cycle progression. Induction of chromosomal condensation and the appearance of a sub-G1 hypodipoid population further supported the proapoptogenicity, possibly through the activation of caspase-3 and caspase-8, and the downregulation of antiapoptotic Bcl-2 and the upregulation of proapoptotic Bax protein expression. Downregulation of mammalian target of rapamycin and upregulation of Atg5 and LC3 II levels in GBM8401 cells implicated the involvement of autophagy. The signaling profiles with mycelial fermentation treatment indicated that mycelial fermentation triggered rapid phosphorylation of Akt, p38 MAPK, and JNK, but suppressed constitutively high levels of ERK1/2 in GBM8401 cells. Mycelial fermentation treatment only significantly increased p38 MAPK phosphorylation, but decreased constitutively high levels of Akt, ERK1/2, and JNK phosphorylation in U-87MG cells. Pretreatment with PI3K inhibitor wortmannin and MEK1 inhibitor PD98059 prevented the mycelial fermentation-induced cytotoxicity in GBM8401 and U-87MG cells, suggesting the involvement of PI3K/Akt and MEK1 pathways in mycelial fermentation-driven glioblastoma cell apoptosis and autophagy.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2012.172
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-11-29
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Biological Factors Research Support, Non-u.s. Gov't Glioblastoma Drug Therapy Pharmacology Metabolism Fermentation Autophagy Drug Effects Cordyceps Physiopathology Jnk Mitogen-activated Protein Kinases Discipline Cell Biology Growth & Development Chemistry Cell Cycle Checkpoints Cell Line, Tumor Genetics Map Kinase Signaling System Mycelium Proto-oncogene Proteins C-bcl-2 Apoptosis
Content Type	Text
Resource Type	Article

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