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Role of the promyelocytic leukaemia protein in cell death regulation.

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Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

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Year: 2011 Volume: 2

Year: 2010 Volume: 1

Role of the promyelocytic leukaemia protein in cell death regulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salomoni, P. Dvorkina, M. Michod, D.
Description	Country affiliation: United kingdom Author Affiliation: Salomoni P ( Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK. p.salomoni@cancer.ucl.ac.uk)
Abstract	The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor . PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2011.122
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-01-12
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Translocation, Genetic Research Support, Non-u.s. Gov't Gene Expression Regulation, Neoplastic Oncogene Proteins, Fusion Leukemia, Promyelocytic, Acute Receptors, Retinoic Acid Cell Death Genetics Transcription, Genetic Cell Differentiation Tretinoin Signal Transduction Neoplastic Stem Cells Metabolism Nuclear Proteins Discipline Cell Biology Pathology Animals Cell Cycle Transcription Factors Mice Tumor Suppressor Proteins Cell Nucleus
Content Type	Text
Resource Type	Article

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