NDLI: Proliferation and tissue remodeling in cancer: the hallmarks revisited.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Markert, E. K. Levine, A. J. Vazquez, A.
Description	Country affiliation: United States Author Affiliation: Markert EK ( The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA.)
Abstract	Although cancers are highly heterogeneous at the genomic level, they can manifest common patterns of gene expression. Here, we use gene expression signatures to interrogate two major processes in cancer, proliferation and tissue remodeling. We demonstrate that proliferation and remodeling signatures are partially independent and result in four distinctive cancer subtypes. Cancers with the proliferation signature are characterized by signatures of p53 and PTEN inactivation and concomitant Myc activation. In contrast, remodeling correlates with RAS, HIF-1 and NFκB activation. From the metabolic point of view, proliferation is associated with upregulation of glycolysis and serine/glycine metabolism, whereas remodeling is characterized by a downregulation of oxidative phosphorylation. Notably, the proliferation signature correlates with poor outcome in lung, prostate, breast and brain cancer, whereas remodeling increases mortality rates in colorectal and ovarian cancer.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2012.140
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-10-04
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Kaplan-meier Estimate Research Support, N.i.h., Extramural Nf-kappa B Cell Proliferation Hypoxia-inducible Factor 1, Alpha Subunit Mortality Oxidative Phosphorylation Gene Expression Profiling Metabolism Neoplasms Discipline Cell Biology Pathology Pten Phosphohydrolase Proto-oncogene Proteins C-myc Tumor Suppressor Protein P53 Ras Proteins Glycolysis Cluster Analysis Epithelial-mesenchymal Transition
Content Type	Text
Resource Type	Article

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