NDLI: Mss4 protein is a regulator of stress response and apoptosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Walter, B. M. Nordhoff, C. Varga, G. Goncharenko, G. Schneider, S. W. Ludwig, S. Wixler, V.
Description	Country affiliation: Germany Author Affiliation: Walter BM ( Institute of Molecular Virology (IMV), Centre of Molecular Biology of Inflammation (ZMBE), Muenster University Hospital, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.)
Abstract	Mss4 (mammalian suppressor of Sec4) is an evolutionarily highly conserved protein and shows high sequence and structural similarity to nucleotide exchange factors. Although Mss4 tightly binds a series of exocytic Rab GTPases, it exercises only a low catalytic activity. Therefore Mss4 was proposed to work rather as a chaperone, protecting nucleotide free Rabs from degradation than as a nucleotide exchange factor. Here we provide further evidence for chaperone-like properties of Mss4. We show that expression levels of cellular Mss4 mRNA and protein are rapidly changed in response to a broad range of extracellular stress stimuli. The alterations are regulated mostly via the (c-jun NH(2)-terminal kinase) JNK stress MAPK signaling pathway and the mode of regulation resembles that of heat shock proteins. Similar to heat shock proteins, upregulation of Mss4 after stress stimulation functions protectively against the programmed cell death. Molecular analysis of the Mss4-mediated inhibition of apoptosis showed that interaction of Mss4 with eIF3f (eukaryotic translation initiation factor 3 subunit f), a member of the translation initiation complex and a protein with distinct pro-apoptotic properties, is the critical event in the anti-apoptotic action of Mss4.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2012.37
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-04-12
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Promoter Regions, Genetic Research Support, Non-u.s. Gov't Molecular Chaperones P38 Mitogen-activated Protein Kinases Dna-binding Proteins Oxidative Stress Rna, Messenger Transcription Factor Ap-1 Metabolism Eukaryotic Initiation Factor-3 Jnk Mitogen-activated Protein Kinases Rab Gtp-binding Proteins Discipline Cell Biology Protein Binding Genetics Transcription Factors Map Kinase Signaling System Hela Cells Apoptosis
Content Type	Text
Resource Type	Article

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