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Year: 2011 Volume: 2

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A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, E-Y Chen, Y-F Chen, Y-M Lin, I-H Wang, C-C Su, W-H Chuang, P-C Yang, K-D
Description	Country affiliation: Taiwan Author Affiliation: Huang EY ( Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.)
Abstract	Galectin-1 is a lectin recognized by galactoside-containing glycoproteins, and is involved in cancer progression and metastasis. The role of galectin-1 in radiosensitivity has not previously been investigated. Therefore, this study tests whether galectin-1 is involved in the radiosensitivity mediated by the H-Ras signaling pathway using cervical carcinoma cell lines. A knockdown of galectin-1 expression in HeLa cells decreased clonogenic survival following irradiation. The clonogenic survival increased in both HeLa and C33A cells with galectin-1 overexpression. The overexpression or knockdown of galectin-1 did not alter radiosensitivity, whereas H-Ras was silenced in both cell lines. Whereas K-Ras was knocked down, galectin-1 restored the radiosensitivity in HeLa cells and C33A cells. The knockdown of galectin-1 increased the high-dose radiation-induced cell death of HeLa cells transfected by constitutively active H-Ras. The knockdown of galectin-1 inhibited the radiation-induced phosphorylation of Raf-1 and ERK in HeLa cells. Overexpression of galectin-1 enhanced the phosphorylation of Raf-1 and ERK in C33A cells following irradiation. Galectin-1 decreased the DNA damage detected using comet assay and Î³-H2AX in both cells following irradiation. These findings suggest that galectin-1 mediates radioresistance through the H-Ras-dependent pathway involved in DNA damage repair.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2011.120
Journal	Cell Death and Disease
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-01-12
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Gamma Rays Research Support, Non-u.s. Gov't Dna Repair Phosphorylation Radiation Tolerance Gene Knockdown Techniques Transfection Histones Genetics Genes, Reporter Gene Expression Signal Transduction Rna, Small Interfering Gene Silencing Metabolism Comet Assay Discipline Cell Biology Proto-oncogene Proteins C-raf Ras Proteins Radiation Effects Galectin 1 Hela Cells
Content Type	Text
Resource Type	Article

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