NDLI: In vitro and in vivo evaluation of SU-8 biocompatibility.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nemani, Krishnamurthy V. Moodie, Karen L. Brennick, Jeoffry B. Su, Alison Gimi, Barjor
Description	Country affiliation: United States Author Affiliation: Nemani KV ( Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.)
Abstract	SU-8 negative photoresist is a high tensile strength polymer that has been used for a number of biomedical applications that include cell encapsulation and neuronal probes. Chemically, SU-8 comprises, among other components, an epoxy based monomer and antimony salts, the latter being a potential source of cytotoxicity. We report on the in vitro and in vivo evaluation of SU-8 biocompatibility based on leachates from various solvents, at varying temperatures and pH, and upon subcutaneous implantation of SU-8 substrates in mice. MTT cell viability assay did not exhibit any cytotoxic effects from the leachates. The hemolytic activity of SU-8 is comparable to that of FDA approved implant materials such as silicone elastomer, Buna-S and medical steel. In vivo histocompatibility study in mice indicates a muted immune response to subcutaneous SU-8 implants.
File Format	HTM / HTML
ISSN	09284931
e-ISSN	18730191
DOI	10.1016/j.msec.2013.07.001
Journal	Materials Science and Engineering: C
Issue Number	7
Volume Number	33
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Materials Science Biocompatible Materials Pharmacology Epoxy Compounds Materials Testing Polymers Agar Animals Antimony Cell Survival Drug Effects Chemistry Hemolysis Immunity Implants, Experimental Mice Mice, Inbred Balb C Organ Specificity Prosthesis Implantation Spectrophotometry, Atomic Staining And Labeling Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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