NDLI: Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miao, Guohou Chen, Xiaofeng Dong, Hua Fang, Liming Mao, Cong Li, Yuli Li, Zhengmao Hu, Qing
Description	Author Affiliation: Miao G ( School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 China.)
Abstract	Acid-catalyzed mesoporous bioactive glass microspheres (MBGMs-A) and acid-alkali co-catalyzed mesoporous bioactive glass microspheres (MBGMs-B) were successfully synthesized via combination of sol-gel and water-in-oil (W/O) micro-emulsion methods. The structural, morphological and textural properties of mesoporous bioactive glass microspheres (MBGMs) were characterized by various techniques. Results show that both MBGMs-A and MBGMs-B exhibit regularly spherical shape but with different internal porous structures, i.e., a dense microstructure for MBGMs-A and internally porous structure for MBGMs-B. (29)Si NMR data reveal that MGBMs have low polymerization degree of silica network. The in vitro bioactivity tests indicate that the apatite formation rate of MBGMs-B was faster than that of MBGMs-A after soaking in simulated body fluid (SBF) solution. Furthermore, the two kinds of MBGMs have similar storage capacity of alendronate (AL), and the release behaviors of AL could be controlled due to their unique porous structure. In conclusion, the microspheres are shown to be promising candidates as bone-related drug carriers and filling materials of composite scaffold for bone repair.
File Format	HTM / HTML
ISSN	09284931
Issue Number	7
Volume Number	33
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Acids Pharmacology Alendronate Alkalies Bone Regeneration Drug Effects Ceramics Chemistry Drug Delivery Systems Glass Microspheres Biocompatible Materials Body Fluids Calcium Analysis Catalysis Emulsions Humans Hydrogen-ion Concentration Magnetic Resonance Spectroscopy Microscopy, Electron, Scanning Nitrogen Particle Size Phosphorus Porosity Silicon Spectroscopy, Fourier Transform Infrared Temperature Thermogravimetry X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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