NDLI: Hydrogel/bioactive glass composites for bone regeneration applications: synthesis and characterisation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Killion, John A. Kehoe, Sharon Geever, Luke M. Devine, Declan M. Sheehan, Eoin Boyd, Daniel Higginbotham, Clement L.
Description	Country affiliation: Ireland Author Affiliation: Killion JA ( Materials Research Institute, Athlone Institute of Technology, Dublin Rd, Athlone, Co. Westmeath, Ireland. jkillion@research.ait.ie)
Abstract	Due to the deficiencies of current commercially available biological bone grafts, alternative bone graft substitutes have come to the forefront of tissue engineering in recent times. The main challenge for scientists in manufacturing bone graft substitutes is to obtain a scaffold that has sufficient mechanical strength and bioactive properties to promote formation of new tissue. The ability to synthesise hydrogel based composite scaffolds using photopolymerisation has been demonstrated in this study. The prepared hydrogel based composites were characterised using techniques including Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy-dispersive X-ray spectrometry (EDX), rheological studies and compression testing. In addition, gel fraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), porosity and swelling studies of the composites were carried out. It was found that these novel hydrogel bioglass composite formulations did not display the inherent brittleness that is typically associated with bioactive glass based bone graft materials and exhibited enhanced biomechanical properties compared to the polyethylene glycol hydrogel scaffolds along. Together, the combination of enhanced mechanical properties and the deposition of apatite on the surface of these hydrogel based composites make them an ideal candidate as bone graft substitutes in cancellous bone defects or low load bearing applications.
File Format	HTM / HTML
ISSN	09284931
Issue Number	7
Volume Number	33
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Bone Regeneration Drug Effects Glass Chemistry Hydrogel Chemical Synthesis Pharmacology Calcification, Physiologic Calorimetry, Differential Scanning Compressive Strength Light Materials Testing Microscopy, Electron, Scanning Polymerization Radiation Effects Porosity Rheology Spectrometry, X-ray Emission Spectroscopy, Fourier Transform Infrared Thermogravimetry X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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