NDLI: PUA/PSS multilayer coated CaCO3 microparticles as smart drug delivery vehicles.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Du, Chao Shi, Jun Shi, Jin Zhang, Li Cao, Shaokui
Description	Country affiliation: China Author Affiliation: Du C ( School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China.)
Abstract	Hybrid CaCO3 microparticles coated by sodium poly(styrene sulfonate) (PSS) and aliphatic poly(urethane-amine) (PUA) were developed as thermal-/pH-responsive drug delivery vehicles via LbL self-assembly technique. The DOX release from the CaCO3 microparticles was higher than 60% within 36 h, whereas the value of PUA/PSS-coated microparticles was only 20%. The results demonstrated that the PUA/PSS multilayer coating could reduce the drug release rate and significantly assuage the initial burst release of DOX. In addition, the drug release of the hybrid microparticles was found to be thermal-/pH-dual responsive. More interestingly, more than 90% of DOX was released in 36 h at pH2.1 and 55 °C owing to the combined action of the dissolution of the CaCO3 core and the shrinkage of aliphatic PUA.
File Format	HTM / HTML
ISSN	09284931
Issue Number	7
Volume Number	33
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Calcium Carbonate Chemistry Coated Materials, Biocompatible Drug Carriers Drug Delivery Systems Particle Size Polystyrenes Polyurethanes Delayed-action Preparations Doxorubicin Hydrogen-ion Concentration Kinetics Microscopy, Electron, Scanning Spectroscopy, Fourier Transform Infrared Static Electricity Temperature Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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