NDLI: Investigation on the properties of linear PLA-poloxamer and star PLA-poloxamine copolymers for temporary biomedical applications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Leroy, Adrien Pinese, Coline Bony, Claire Garric, Xavier Noël, Danièle Nottelet, Benjamin Coudane, Jean
Description	Country affiliation: France Author Affiliation: Leroy A ( Institut des Biomolécules Max Mousseron (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2-Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier, 34093, France.)
Abstract	The objective of this work was to develop and study new biodegradable thermoplastics with improved mechanical properties for potential use as temporary implantable biomaterials. Linear poloxamer and star-shaped poloxamine have been used as macroinitiators for the ring-opening polymerization (ROP) of lactide to yield high molecular weight PLA-based thermoplastic block copolymers. The influence of the nature of the macroinitiator, PLA crystallinity and initial molecular weight on the copolymers properties was investigated by performing a 7-week degradation test in PBS. The evaluation of water uptakes and molecular weights during the degradation pointed out an early hydrolytic degradation of the 100-kgâmol(-1) copolymers compared to the 200-kgâmol(-1) ones (molecular weight decrease of ca. 40% and 20%, respectively). A dramatic loss of tensile mechanical properties was also observed for the 100-kgâmol(-1) copolymers, whereas the 200-kgâmol(-1) copolymers showed stable or even slightly improved properties with Young's moduli around 500 MPa and yield strains around 3% to 4%. Finally, the cytocompatibility of the more stable 200 kgâmol(-1) copolymers was confirmed by murine mesenchymal stem cells (MSCs) culture.
File Format	HTM / HTML
ISSN	09284931
Issue Number	7
Volume Number	33
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Biomedical Technology Methods Ethylenediamines Chemistry Lactic Acid Poloxamer Polymers Animals Cell Death Drug Effects Cell Line Cell Proliferation Chromatography, Gel Chemical Synthesis Pharmacology Materials Testing Mechanical Phenomena Mesenchymal Stromal Cells Cytology Mice Microscopy, Fluorescence Molecular Weight Polyesters Temperature Water Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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