NDLI: Electrochemical investigation of the voltammetric determination of hydrochlorothiazide using a nickel hydroxide modified nickel electrode.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Machini, Wesley B. S. David-Parra, Diego N. Teixeira, Marcos F. S.
Description	Country affiliation: Brazil Author Affiliation: Machini WB ( Faculty of Science and Technology, São Paulo State University (UNESP), CEP 19060-900 Presidente Prudente, SP, Brazil.); David-Parra DN ( Faculty of Science and Technology, São Paulo State University (UNESP), CEP 19060-900 Presidente Prudente, SP, Brazil.); Teixeira MF ( Faculty of Science and Technology, São Paulo State University (UNESP), CEP 19060-900 Presidente Prudente, SP, Brazil. Electronic address: funcao@fct.unesp.br.)
Abstract	The preparation and electrochemical characterization of a nickel hydroxide modified nickel electrode as well as its behavior as electrocatalyst toward the oxidation of hydrochlorothiazide (HCTZ) were investigated. The electrochemical behavior of the modified electrode and the electrooxidation of HCTZ were explored using cyclic voltammetry. The voltammetric response of the modified electrode in the detection of HCTZ is based on the electrochemical oxidation of the Ni(II)/Ni(III) and a chemical redox process. The analytical parameters for the electrooxidation of HCTZ by the nickel hydroxide modified nickel electrode were obtained in NaOH solution, in which the linear voltammetric response was in the concentration range from 1.39×10(-5) to 1.67×10(-4)mol L(-1) with a limit of detection of 7.92×10(-6)mol L(-1) and a sensitivity of 0.138 µA Lmmol(-1). Tafel analysis was used to elucidate the kinetics and mechanism of HCTZ oxidation by the modified electrode.
File Format	HTM / HTML
ISSN	09284931
Volume Number	57
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2015-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Conductometry Instrumentation Electrodes Hydrochlorothiazide Urine Hydroxides Chemistry Nickel Performance-enhancing Substances Substance Abuse Detection Diuretics Doping In Sports Prevention & Control Equipment Design Equipment Failure Analysis Humans Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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