NDLI: Synthesis of different sized and porous hydroxyapatite nanorods without organic modifiers and their 5-fluorouracil release performance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ji, Yuqin Wang, Aili Wu, Gang Yin, Hengbo Liu, Shuxin Chen, Bujun Liu, Fanggang Li, Xiaoyun
Description	Country affiliation: China Author Affiliation: Ji Y ( Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.); Wang A ( Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.); Wu G ( Department of Stomatology, Chinese PLA 359 Hospital, Zhenjiang 212006, China.); Yin H ( Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: yin@ujs.edu.cn.); Liu S ( School of Chemistry and Chemical Engineering, Mianyang Normal University, Mianyang 621000, China.); Chen B ( Department of Orthopaedics, Chinese PLA 359 Hospital, Zhenjiang 212006, China.); Liu F ( Department of Orthopaedics, Chinese PLA 359 Hospital, Zhenjiang 212006, China.); Li X ( Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.)
Abstract	Porous biocompatible hydroxyapatite (HAP) nanorods of various sizes were synthesized by the combination of chemical precipitation and hydrothermal method without the use of organic modifiers. The HAP nanorod samples were characterized by powder X-ray diffraction, transmission electron microscopy, and N2 adsorption/desorption techniques. HAP nanorods with average diameters and average lengths ranging from 8.5 to 26.6 nm and from 23.1 to 49.7 nm, respectively, could be controllably synthesized via these methods. Low autoclaving temperature and high pH value favored the formation of relatively small HAP nanorods. The TEM images showed that the nanorods possessed porous structures with average pore diameters ranging from 1.6 to 2.7 nm. These HAP nanoparticles effectively prolonged the release time of 5-fluorouracil up to 24h. The as-synthesized HAP nanorods displayed no cytotoxicity to bone marrow stem cells at low HAP concentration, indicating that these nanorod materials could serve as potential carriers for novel drug release systems.
File Format	HTM / HTML
ISSN	09284931
Volume Number	57
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2015-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Delayed-action Preparations Chemistry Durapatite Fluorouracil Nanocapsules Nanopores Ultrastructure Nanotubes Absorption, Physicochemical Antimetabolites, Antineoplastic Administration & Dosage Diffusion Organic Chemicals Particle Size Porosity Comparative Study Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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