NDLI: Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide-Au nanomaterials.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guo, Zhuo Wang, Ze-Yu Wang, Hui-Hua Huang, Guo-Qing Li, Meng-Meng
Description	Author Affiliation: Guo Z ( Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China. Electronic address: guozhuochina@syuct.edu.cn.); Wang ZY ( Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.); Wang HH ( Shagang School of Iron and Steel, Soochow University, Suzhou 215021, China. Electronic address: hhwang@suda.edu.cn.); Huang GQ ( Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.); Li MM ( Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.)
Abstract	A sensitive electrochemical sensor has been fabricated to detect Isoniazid (INZ) using reduced graphene oxide (RGO) and Au nanocomposites (RGO-Au). RGO-Au nanocomposites were synthesized by a solution-based approach of chemical co-reduction of Au(III) and graphene oxide (GO), and were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, and Fourier transform infrared (FT-IR). The Au nanoparticles separate the RGO sheets in the precipitate and prevent RGO sheets from aggregation upon π-π stacking interactions. RGO-Au nanocomposites were used to modify the glassy carbon electrode (GCE). The electrochemical properties of RGO-Au/GCE were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and the RGO-Au/GCE exhibited remarkably strong electrocatalytic activities towards INZ. Under the optimized conditions, there was linear relationships between the peak currents and the concentrations in the range of 1.0×10(-7)M to 1.0×10(-3)M for INZ, with the limit of detection (LOD) (based on S/N=3) of 1.0×10(-8)M for INZ.
File Format	HTM / HTML
ISSN	09284931
Volume Number	57
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2015-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Biosensing Techniques Instrumentation Conductometry Gold Chemistry Graphite Isoniazid Analysis Microelectrodes Carbon Equipment Design Equipment Failure Analysis Glass Metal Nanoparticles Ultrastructure Nanocomposites Oxidation-reduction Oxides Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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