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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Das, Anup K. Bag, Sujit Sahu, Ranabir Dua, Tarun K. Sinha, Mohit K. Gangopadhyay, Moumita Zaman, Kamaruz Dewanjee, Saikat |
| Description | Country affiliation: India Author Affiliation: Das AK ( Department of Pharmaceutical Sciences, Dibrugarh University, Assam, India.) |
| Abstract | The present study was undertaken to evaluate the protective effect of aqueous extract of Corchorus olitorius leaves (AECO) against sodium arsenite-induced toxicity in experimental rats. The animals exposed to sodium arsenite at a dose of 10mg/kg body weight p.o. for 10days exhibited a significant inhibition (p<0.01) of hepatic and renal antioxidant enzymes namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase and glutathione reductase. In addition, arsenic intoxication significantly decreased (p<0.01) the level of reduced glutathione and increased (p<0.01) the levels of oxidized glutathione and thiobarbituric acid reactive substances in selected tissues. Treatment with AECO at doses of 50 and 100mg/kg body weight p.o. for 15days prior to arsenic intoxication significantly improved hepatic and renal antioxidant markers in a dose dependant manner. AECO treatment also significantly reduced the arsenic-induced DNA fragmentation of hepatic and renal tissues. Histological studies on the ultrastructural changes of liver and kidney supported the protective activity of the AECO. The results concluded that the treatment with AECO prior to arsenic intoxication has significant role in protecting animals from arsenic-induced hepatic and renal toxicity. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 1 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Arsenites Antagonists & Inhibitors Toxicity Corchorus Chemistry Sodium Compounds Animals Catalase Metabolism Dna Fragmentation Flavonoids Analysis Pharmacology Glutathione Glutathione Peroxidase Kidney Drug Effects Pathology Kidney Function Tests Lipid Peroxidation Liver Liver Function Tests Male Oxidative Stress Phenols Plant Extracts Plant Leaves Polyphenols Quercetin Rats Rats, Wistar Superoxide Dismutase Thiobarbituric Acid Reactive Substances Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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