NDLI: Appraisal of in vitro and in vivo antioxidant activity potential of cornelian cherry leaves.

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Appraisal of in vitro and in vivo antioxidant activity potential of cornelian cherry leaves.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Celep, Engin Aydin, Ahmet Kirmizibekmez, Hasan Yesilada, Erdem
Description	Country affiliation: Turkey Author Affiliation: Celep E ( Yeditepe University, Faculty of Pharmacy, Department of Pharmacognosy, Atasehir, 34755 Istanbul, Turkey.)
Abstract	The antioxidant activity of the 80% methanolic extract of Cornus mas L. leaves (CMM) was evaluated by various methods both in vitro and in vivo. In vitro screening tests indicated that CMM had high antioxidant activity in terms of free radical scavenging and metal reducing activity. In vivo antioxidant activity studies in normal healthy rats demonstrated that the total antioxidant capacity of liver homogenates were increased, although no changes were observed in the activities of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase or in the level of lipid peroxidation. Studies on CCl4-treated rats also showed that CMM restored the activities of antioxidant enzymes, lowered the level of lipid peroxidation and elevated the total antioxidant capacities of both the total blood and liver homogenates of the animals. Further activity-guided fractionation studies led to the isolation of gallic acid, a well-known antioxidant, as one of the active components.
File Format	HTM / HTML
ISSN	02786915
Volume Number	62
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Antioxidants Pharmacology Cornus Chemistry Plant Extracts Animals Carbon Tetrachloride Toxicity Catalase Metabolism Flavonoids Analysis Gallic Acid Isolation & Purification Glutathione Peroxidase Lipid Peroxidation Drug Effects Liver Male Plant Leaves Proanthocyanidins Rats Rats, Sprague-dawley Superoxide Dismutase Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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