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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ananthi, Subash Raghavendran, Hanumantha Rao Balaji Sunil, Adoor Gopalan Gayathri, Veeraraghavan Ramakrishnan, Ganapathy Vasanthi, Hannah R. |
| Description | Country affiliation: India Author Affiliation: Ananthi S ( Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, Porur, Chennai 600 116, India.) |
| Abstract | Water-soluble crude polysaccharide from a brown alga Turbinaria ornata (TCP) was screened for its antioxidant and anti-inflammatory potential. The major functional groups of polysaccharide were analyzed by Fourier Transmission-Infra Red (FT-IR). In vitro free radical quenching and total antioxidant activity of TCP was investigated by 1, 1-diphenyl-2-picryl hydrazyl (DPPH), nitric oxide (NO) scavenging, lipid peroxidation (LPO) inhibition and ABTS radical assay. Evaluation of anti-inflammatory activity of TCP was performed using carrageenan-induced paw edema in rats and vascular permeability test in mice. Phytochemical analysis of TCP showed the presence of carbohydrates, proteins and polyphenols further, the FT-IR analysis of TCP showed the presence of functional groups of sugar moiety, uronic acids and sulfate groups. TCP showed maximum LPO, NO and DPPH inhibition of 78.04%, 38.82% and 80.21% at a concentration of 1000, 125 and 500 microg/ml respectively. Oral administration of TCP (2.5, 5, 10, 20mg/kg) reduced the paw edema considerably (p<0.05) in a dose dependent manner compared to carrageenan induced rats. Similarly, oral administration of TCP (3, 10, 30 mg/kg) evoked a significant (p<0.05) dose dependent inhibitory effect on vascular permeability in mice. Altogether, these results suggest that the crude polysaccharide of T.ornata could be considered as a potential antioxidant and anti-inflammatory agent. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 1 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Anti-inflammatory Agents, Non-steroidal Pharmacology Antioxidants Phaeophyta Chemistry Polysaccharides Animals Biphenyl Compounds Capillary Permeability Drug Effects Carrageenan Edema Chemically Induced Prevention & Control Female Foot Pathology Indicators And Reagents Lipid Peroxidation Mice Nitric Oxide Metabolism Nitroprusside Oxidants Picrates Rats Rats, Sprague-dawley Spectroscopy, Fourier Transform Infrared Thiobarbituric Acid Reactive Substances Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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