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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Doi, Yuko Furukawa, Fumio Suguro, Mayuko Ito, Hikaru Imai, Norio Nabae, Kyoko Toda, Yosuke Inatomi, Satoshi Kinugasa, Satomi Kobayashi, Hitoshi |
| Description | Country affiliation: Japan Author Affiliation: Doi Y ( DIMS Institute of Medical Science, Inc, 64 Goura, Nishiazai, Azai-cho, Ichinomiya 491-0113, Japan. doidoi@dims.co.jp) |
| Abstract | The modifying potential of Agaricus blazei Murrill fruit-body extract (ABFE) on tumor development was investigated in a medium-term multi-organ carcinogenesis bioassay. Male 6-week-old F344 rats were treated with N-nitrosodiethylamine (DEN), N-methyl-N-nitrosourea (MNU), 1,2-dimethylhydrazine dihydrochloride (DMH), N-butyl-N-(hydroxybutyl)-nitrosamine (BBN), and diisopropanolnitrosamine (DHPN) for initiation (DMBDD treatment). After a 1-week withdrawal period, the animals received distilled water (vehicle control) or ABFE A, gamma-amino butyric acid (GABA) at 0.8 mg/kg, ABFE B (GABA level of 3.0mg/kg) or ABFE C (GABA level of 12.0mg/kg) by gavage for 24 weeks. There were no effects of ABFE on survival rate, general condition, body weight, food and water consumption, and organ weights. The multiplicity of large intestinal nodules, smaller than 2mm was significantly increased in the ABFE C group with DMBDD treatment. However, there were no significantly inter-group differences in incidences of hyperplastic or neoplastic lesions in colon or other organs, or in immunohistochemically identified preneoplastic lesions in the liver. In conclusion, A. blazei Murrill fruit-body extract, even at a GABA level up to 12 mg/kg, did not exert modifying potential in the present medium-term multi-organ carcinogenesis bioassay in male F344 rats (DMBDD method). |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 1 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Agaricus Chemistry Carcinogens Antagonists & Inhibitors Toxicity Fruiting Bodies, Fungal Animals Body Weight Drug Effects Drinking Eating Female Glutathione Transferase Metabolism Hyperplasia Chemically Induced Pathology Immunohistochemistry Male Neoplasms Organ Size Precancerous Conditions Rats Rats, Inbred F344 Survival Analysis Gamma-aminobutyric Acid Pharmacology Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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