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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dua, Raina Sunkaria, Aditya Kumar, Vijay Gill, Kiran Dip |
| Description | Country affiliation: India Author Affiliation: Dua R ( Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.) |
| Abstract | The present study was designed with an aim to analyze the effect of acute aluminium phosphide (ALP) exposure (10mg/kg b.wt, intragastrically) on the kinetic characteristics of cytochrome oxidase and energy metabolism in male Wistar rat liver mitochondria. Liver mitochondrial preparations from ALP-treated rats exhibited significant decrease (66%) in the activity of cytochrome oxidase suggesting that there was a decrease in the catalytic efficiency of the active oxidase molecules on ALP treatment. The decreased activity of cytochrome oxidase with altered NADH and succinic dehydrogenase activities might have contributed towards a significant decline in state 3 and state 4 respiration as observed. These alterations in the electron transport chain complexes in turn adversely affected the ATP synthesis rate as well as ATP levels in the mitochondria isolated from treated rats. The alterations in the respiratory chain, was followed by enhanced lipid peroxidation in rat liver mitochondria which might have further contributed to change in the fluidity of membrane as depicted by decreased fatty acid content of liver mitochondria. However, no significant change was observed in cholesterol and phospholipids content in our study. The present study thus highlights the significance of altered mitochondrial respiratory chain functions and membrane integrity after acute ALP exposure. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 1 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Aluminum Compounds Toxicity Electron Transport Complex Iv Metabolism Energy Metabolism Drug Effects Mitochondria, Liver Pesticides Phosphines Adenosine Triphosphatases Adenosine Triphosphate Biosynthesis Animals Cholesterol Analysis Fatty Acids Chemistry In Vitro Techniques Kinetics Lethal Dose 50 Lipid Peroxidation Male Membrane Fluidity Nadph Dehydrogenase Phospholipids Rats Rats, Wistar Succinate Dehydrogenase Temperature Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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