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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ho, Hsieh-Hsun Hsu, Li-Sung Chan, Kuei-Chuan Chen, Hsiang-Mei Wu, Cheng-Hsun Wang, Chau-Jong |
| Description | Author Affiliation: Ho HH ( Institute of Biochemistry and Biotechnology, Chung Shan Medical University, South District, Taichung City 402, Taiwan, ROC.) |
| Abstract | Nelumbo nucifera GAERTN, a perennial aquatic plant, has been used as a medicinal herb in China and India. We have previously reported that consumption of nucifera leaf extract (NLE) reduced the development of atherosclerosis in cholesterol-fed rabbits; however, the molecular mechanisms involved were unclear. Atherosclerotic plaque is generated partly by proliferation and migration of vascular smooth muscle cells (VSMC). Herein, we demonstrated that VSMC treated with NLE-triggered apoptosis and affected the JNK and p38 Mitogen-Activated Protein Kinase (MAPK) pathways. Pre-treating VSMC with inhibitors of JNK, p38, and p53 reduced NLE-induced apoptosis. Non-cytotoxic doses of NLE also abolished secretion of MMP-2/9 and inhibited cell migration via restraining the FAK/PI 3-kinase/small G protein pathway. Histopathological examination showed that 1.0% of NLE reduced neointima formation conspicuously and inhibited smooth muscle cell proliferation and MMP-2 secretion in the blood vessel of rabbits fed with a high cholesterol diet (HCD). We also verified that the extract's total phenolic acids and the total flavonoids were approximately about 70%. In conclusion, our results shed light on the molecular mechanisms whereby the polyphenol-rich water extract of nucifera leaves could inhibit both proliferation and migration of VSMC, and it might serve as a potential anti-atherogenic agent. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 1 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Arecaceae Chemistry Atherosclerosis Prevention & Control Myocytes, Smooth Muscle Drug Effects Animals Apoptosis Pathology Blotting, Western Cell Line Cell Movement Cell Proliferation Coloring Agents Dna Fragmentation Flow Cytometry Fluorescent Dyes In Vitro Techniques Indoles Plant Extracts Pharmacology Plant Leaves Rabbits Rats Tetrazolium Salts Thiazoles Tumor Suppressor Protein P53 Biosynthesis Wound Healing Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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